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LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

Nature Genetics volume 5, pages 66–70 (1993)Cite this article

Abstract

We have shown previously that chromosomal translocations involving chromosome 3q27 and immunoglobulin gene regions are the third most common specific translocations in non–Hodgkin's lymphoma (NHL). We now report the isolation of a gene that is disrupted in two cases by t(3;14) and t(3;4) translocations. The gene (LAZ3) encodes a 79 kDa protein containing six zinc–finger motifs and sharing amino–terminal homology with several transcription factors including the Drosophila tramtrack and Broad–complex genes, both of which are developmental transcription regulators. LAZ3 is transcribed as a 3.8 kb message predominantly in normal adult skeletal muscle and in several NHL carrying 3q27 chromosomal defects. We suggest that it may act as a transcription regulator and play an important role in lymphomagenesis.

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Authors and Affiliations

  1. Unité 124 INSERM, Institut de Recherches sur le Cancer de Lille, Place de Verdun, 59045, Lille cedex, France

    Jean-Pierre Kerckaert, Clotilde Deweindt, Sabine Quief & Gérard Lecocq

  2. Centre Henri Becquerel, rue d'Amiens, 76038, Rouen, France

    Hervé Tilly

  3. Departement de Cytogénétique, Centre Régional de transfusion sanguine, 609 chemin de la Bretèque, BP 58, 76232, Bois-Guillaume Cedex, France

    Christian Bastard

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  1. Jean-Pierre Kerckaert
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  2. Clotilde Deweindt
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  3. Hervé Tilly
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  4. Sabine Quief
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  5. Gérard Lecocq
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  6. Christian Bastard
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Kerckaert, JP., Deweindt, C., Tilly, H. et al. LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat Genet 5, 66–70 (1993). https://doi.org/10.1038/ng0993-66

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