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A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Abstract

F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and β thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.

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Figure 1: Association statistics (−log10(P)) for individuals included in the genome-wide screening panel.

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References

  1. Thein, S.L. & Craig, J.E. Hemoglobin 22, 401–414 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Steinberg, M.H., Forget, B.G., Higgs, D.R. & Nagel, R.L. (eds.). Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management (Cambridge Univ. Press, Cambridge, 2001).

    Google Scholar 

  3. Bank, A. Blood 107, 435–443 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Garner, C. et al. Blood 95, 342–346 (2000).

    CAS  PubMed  Google Scholar 

  5. Garner, C. et al. GeneScreen 1, 9–14 (2000).

    Article  CAS  Google Scholar 

  6. Thein, S.L. et al. Proc. Natl. Acad. Sci. USA 104, 11346–11351 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. Spector, T.D. & MacGregor, A.J. Twin Res. 5, 440–443 (2002).

    Article  PubMed  Google Scholar 

  8. Tenesa, A., Visscher, P.M., Carothers, A.D. & Knott, S.A. Behav. Genet. 35, 219–228 (2005).

    Article  PubMed  Google Scholar 

  9. Devlin, B. & Roeder, K. Biometrics 55, 997–1004 (1999).

    Article  CAS  PubMed  Google Scholar 

  10. Patterson, N., Price, A.L. & Reich, D. PLoS Genet. 2, e190 (2006) (doi:10.1371/journal.pgen.0020190).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Craig, J.E. et al. Nat. Genet. 12, 58–64 (1996).

    Article  CAS  PubMed  Google Scholar 

  12. Liu, P. et al. Nat. Immunol. 4, 525–532 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. International HapMap Consortium. Nature 437, 1299–1320 (2005).

  14. Abecasis, G.R., Cardon, L.R. & Cookson, W.O. Am. J. Hum. Genet. 66, 279–292 (2000).

    Article  CAS  PubMed  Google Scholar 

  15. Senawong, T., Peterson, V.J. & Leid, M. Arch. Biochem. Biophys. 434, 316–325 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank C. Steward for help in preparation of the manuscript. This work was supported by a grant from the UK Medical Research Council (MRC; G0000111 and ID 51640) to S.L.T. and by the French Ministry of Higher Education and Research (M.L.). Twins UK is supported by the Wellcome Trust and Framework V EU (European Union) grant 'Genome EU Twin'.

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Authors and Affiliations

Authors

Contributions

S.M. performed research, analyzed data and wrote the paper; C.G. analyzed data; M.Y. and M. Foglio performed bioinformatics analyses; I.G. and S.H. performed genome-wide association genotyping; D.Z., A.B., H.R., and S.B. performed research; T.D.S. contributed material; M. Farrall performed statistical genetic analysis and wrote the paper; M.L. codirected the research, analyzed data and wrote the paper; S.L.T. codirected the research and wrote the paper.

Corresponding author

Correspondence to Swee Lay Thein.

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Supplementary Methods, Supplementary Tables 1–4, Supplementary Figures 1–3 (PDF 900 kb)

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Menzel, S., Garner, C., Gut, I. et al. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet 39, 1197–1199 (2007). https://doi.org/10.1038/ng2108

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