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Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons

Nature Neuroscience volume 5, pages 719–720 (2002)Cite this article

Abstract

Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up the only precursor population known to migrate away from the surface of the brain. We studied the role of the chemokine stromal-derived factor 1 (SDF-1) in the cerebellar tissue of rats and knockout mice and found (i) that it functions as an attractive guidance cue for neuronal migration and (ii) that its secretion from non-neuronal meningeal tissue is important for controlling the migration of embryonic EGL cells.

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Figure 1: Expression of the SDF-1 protein in the meninges.
Figure 2: Responses of EGL cells to SDF-1.
Figure 3: Analysis of explants from mice lacking the SDF-1 gene.

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Acknowledgements

We are grateful to the USNational Institutes of Health (NIH), the Klingenstein foundation, the John Merck fund and the Leukemia Society of America for support (to Y.R. and J.Y.W.).

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, 63110, Missouri, USA

    Yan Zhu, Tao Yu & Yi Rao

  2. Department of Pediatrics, Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, 63110, Missouri, USA

    Xiao-Chun Zhang & Jane Y. Wu

  3. Department of Molecular and Cellular Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, 840 Murodo-cho, Izumi, 594-1101, Osaka, Japan

    Takashi Nagasawa

Authors
  1. Yan Zhu
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  2. Tao Yu
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Correspondence to Jane Y. Wu or Yi Rao.

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Zhu, Y., Yu, T., Zhang, XC. et al. Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci 5, 719–720 (2002). https://doi.org/10.1038/nn881

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