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Mre11: roles in DNA repair beyond homologous recombination

Nature Structural & Molecular Biology volume 16, pages 798–800 (2009)Cite this article

The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 also has a role in mammalian DNA double-strand break repair by nonhomologous end joining.

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Figure 1: Potential Mre11 functions in C-NHEJ and A-NHEJ pathways.
Figure 2: The multiple functions of Mre11.

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Authors and Affiliations

  1. Shan Zha, Cristian Boboila, Frederick W. Alt are at the Howard Hughes Medical Institute, The Children's Hospital, The CBR institute of Biomedical Research, Harvard Medical School, Boston, Massachusetts, USA.,

    Shan Zha, Cristian Boboila & Frederick W Alt

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  1. Shan Zha
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  2. Cristian Boboila
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  3. Frederick W Alt
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Correspondence to Frederick W Alt.

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Zha, S., Boboila, C. & Alt, F. Mre11: roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol 16, 798–800 (2009). https://doi.org/10.1038/nsmb0809-798

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