Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Cord Blood Banking

Development of a district Cord Blood Bank: a model for cord blood banking in the National Health Service

Bone Marrow Transplantation volume 25, pages 899–905 (2000)Cite this article

Abstract

The Bristol Cord Blood Bank was established as a pilot project within existing health services to establish cost-effective recruitment, collection and processing suitable for use in the NHS should cord blood become a routine source of haemopoietic stem cells for transplantation in the UK. An important aim of the project was to evaluate the feasibility of establishing a midwifery-based collection network, thus utilising expertise already in place. Collection was performed on the delivery suite immediately after the placenta was delivered. The clinical experience of the midwife collector/counsellors allowed rapid pre-collection assessment of the condition of the cord and placenta. This prevented collection attempts from diseased or otherwise damaged placentas, leading to conservation of resources by preventing collection of most small volume donations. The bank was established within the National Blood Service, Bristol Centre to achieve Good Manufacturing Practice standards and ensure that processing was subject to the same stringency required for other sources of haemopoietic stem cells. Cord blood is an expensive resource. By utilising existing expertise in district Obstetric and National Blood Services, the Bristol Cord Blood Bank may serve as a model for health economic evaluation of cord blood banking of volunteer donations within the NHS. Bone Marrow Transplantation (2000) 25, 899–905.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gluckman E, Broxmeyer HA, Auerbach AD et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling New Engl J Med 1989 321: 1174–1178

    Article  CAS  Google Scholar 

  2. Rubinstein P, Carrier C, Scaradavou A et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors New Engl J Med 1998 339: 1565–1577

    Article  CAS  Google Scholar 

  3. Locatelli F, Rocha V, Chastang C et al. Factors associated with outcome after cord blood transplantation in children with acute leukemia Blood 1999 93: 3662–3671

    CAS  Google Scholar 

  4. Gluckman E, Rocha V, Boyer-Chammard A et al. Outcome of cord-blood transplantation from related and unrelated donors New Engl J Med 1997 337: 373–381

    Article  CAS  Google Scholar 

  5. Wagner JE, DeFor T, Rubinstein P et al. Transplantation of unrelated donor umbilical cord blood (UCB): outcomes and analysis of risk factors Blood 1997 90: (Suppl. 1) 398 (Abstr. 1767)

    Google Scholar 

  6. UKBTS/NIBSC Guidelines for the Blood Transfusion Service, 3rd edn HMSO: London 1996

  7. Rubinstein P, Rosenfield RE, Adamson JW et al. Stored placental blood for unrelated bone marrow reconstitution Blood 1993 81: 1679–1690

    CAS  PubMed  Google Scholar 

  8. Donaldson C, Armitage WJ, Laundy V et al. Impact of obstetric factors on cord blood donation for transplantation Br J Haematol 1999 106: 128–132

    Article  CAS  Google Scholar 

  9. Wall DA, Noffsinger JM, Mueckl KA et al. Feasibility of an obstetrician-based cord blood collection network for unrelated donor umbilical cord blood banking J Matern-Fetal Med 1997 6: 321–323

    Article  Google Scholar 

  10. Surbek DV, Schönfeld B, Tichelli A et al. Optimizing cord blood mononuclear cell yield: a randomized comparison of collection before vs after placenta delivery (letter) BoneMarrow Transplant 1998 22: 311–312

    CAS  Google Scholar 

  11. Marchand P, Pellegrini N, Petit-Prost E et al. Experience of the Besançon cord blood bank Bone Marrow Transplant 1998 21: (Suppl. 1) S22 (Abstr. 78)

    Google Scholar 

  12. Lecchi L, Ratti I, Garcea F et al. Cord blood unit deferral rate and causes. 3rd Eurocord Transplant Concerted Action Workshop, Annecy, France 1998, (Abstr. 38)

  13. Richter E, Eichler H, Leveringhaus A et al. The Mannheim cord blood project: data on volume reduction by buffy coat preparation of 209 cord blood samples Bone Marrow Transplant 1998 21: (Suppl. 1) S22 (Abstr. 79)

    Google Scholar 

  14. Bries G, Uttebroek A, Spitz B et al. The Leuven cord blood banking project: logistics and results 3rd Eurocord Transplant Concerted Action Workshop, Annecy, France 1998 (Abstr. 57)

    Google Scholar 

  15. Armitage S, Warwick R, Fehily D et al. Cord blood banking in London: the first 1000 collections Bone Marrow Transplant 1999 24: 139–145

    Article  CAS  Google Scholar 

  16. Rubinstein P, Dobrila L, Rosenfield RE et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution Proc Natl Acad Sci USA 1995 92: 10119–10122

    Article  CAS  Google Scholar 

  17. UKBTS/NIBSC Medical Assessment of Donors Document HMSO: London 1998

  18. Engelfriet CP, Reesink HW, Wagner JE et al. Use of cord blood progenitor cells as an alternative for bone marrow transplantation Vox Sang 1998 75: 156–172

    Article  CAS  Google Scholar 

  19. Ademokun JA, Chapman C, Dunn J et al. Umbilical cord blood collection and separation for haematopoietic progenitor cell banking Bone Marrow Transplant 1997 19: 1023–1028

    Article  CAS  Google Scholar 

  20. Armitage S, Fehily D, Dickinson A et al. Cord blood banking: volume reduction of cord blood units using a semi-automated closed system Bone Marrow Transplant 1999 23: 505–509

    Article  CAS  Google Scholar 

  21. Donaldson C, Armitage WJ, Denning-Kendall PA et al. Optimal cryopreservation of human umbilical cord blood Bone Marrow Transplant 1996 18: 725–731

    CAS  PubMed  Google Scholar 

  22. Kurtzberg J, Laughlin M, Graham ML et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients New Engl J Med 1996 335: 157–166

    Article  CAS  Google Scholar 

  23. Wagner JE, Kernan NA, Steinbuch M et al. Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease Lancet 1995 346: 214–219

    Article  CAS  Google Scholar 

  24. Migliaccio A, Addinson J, Rubinstein P et al. Correlation between progenitor cell dose and time to myeloid engraftment in 79 unrelated placental/cord blood transplants Exp Hematol 1997 25: 350 (Abstr. 356)

    Google Scholar 

  25. Gian VG, Moreb JS, Abdel-Mageed A et al. Successful salvage using mismatched umbilical cord blood transplant in an adult with recurrent acute myelogenous leukemia failing autologous peripheral blood progenitor cell transplant: a case history and review Bone Marrow Transplant 1998 21: 1197–1200

    Article  CAS  Google Scholar 

  26. Sirchia G, Rebulla P, Tibaldi S et al. Cost of umbilical cord blood units released for transplantation Transfusion 1999 39: 645–650

    Article  CAS  Google Scholar 

  27. Hows J, Downie T, Nunn A et al. Fate of patients undergoing unrelated donor (UD) searches in the UK Bone Marrow Transplant 1996 17: S56 (Abstr. 269)

    Google Scholar 

  28. Kögler G, Callejas J, Hakenberg P et al. Hematopoietic transplant potential of unrelated cord blood: critical issues J Hematother 1996 5: 105–116

    Article  Google Scholar 

Download references

Acknowledgements

The Bristol Cord Blood Bank is funded by the Leukaemia Research Fund grant 96/04, jointly with the Bristol Institute of Transfusion Sciences; Director Professor D Anstee. We thank Dr D Pamphilon and staff at the Bristol Transfusion Centre for the use of laboratory facilities; Dr A MacGowan, Consultant Microbiologist, for advice throughout the project; the midwives on CDS and other members of the Department of Obstetrics and Gynaecology, Southmead Hospital, for their enthusiastic support of the project and all the mothers who donated cord blood to the bank.

We would like to thank all the GPs and community midwives from the following practices without whose help this project would not have been possible: 2 Riverleaze Practice, Sea Mills; 33 North Street Practice, Downend; 227 Lodge Causeway Practice, Fishponds; Air Balloon Surgery, St George; Avonmouth Medical Centre; Berkley Health Centre; Bradgate Surgery, Brentry; Bradley Stoke Surgery; Brockway Medical Centre, Nailsea; Brooklea Health Centre, Brislington; Brunston Surgery, Cinderhill, Coleford; Cadbury Health Centre; Cheddar Medical Centre; Chew Magna Surgery; Coalpit Heath Surgery; Clevedon Health Centre; Close Farm Surgery, North Common; Coniston Medical Practice, Patchway; Corbett House Clinic, Barton Hill; Courtside Surgery, Yate; Downland Surgery, Worle; Eastville Health Centre; Fishponds Health Centre; Gable House Surgery, Malmesbury; Gaywood House Surgery, Bedminster; Gloucester Road Medical Centre, Horfield; Graham Road Surgery, Weston Super Mare; Hanham Surgery; Harptree Surgery, West Harptree; Hartcliffe Health Centre; Heywood Surgery, Pill; Horfield Health Centre; Kennedy Way Surgery, Yate; Kingswood Health Centre; Lawrence Hill Health Centre, Easton; Lodgeside Surgery, Kingswood; Lydney Health Centre; Montpelier Health Centre; Nailsea Health Centre Practice; Oldland Surgery Practice, Oldland Common; Portishead Health Centre; Riverbank Medical Centre, Worle; Rowcroft Medical Centre, Stroud; St Augustines Practice, Keynsham; St George Health Centre; St Johns Lane Health Centre, Bedminster; Shirehampton Health Centre; Sneyd Park Surgery; Southmead Health Centre; Spence Group Practice, Redland; Station Road Surgery, Congresbury; Stockwood Health Centre; Stoke Gifford Medical Centre; Sussex Place Surgery, Bristol; The Chipping Surgery, Wickwar; The Chipping Surgery, Wotton-under-Edge; The Malago Surgery, Bedminster; The Medical Centre, Ridingleaze, Lawrence Weston; The Orchard Medical Centre, Kingswood; The Stokes Medical Centre, Little Stoke; The Surgery, 2 Back Lane, Pucklechurch; The Surgery, 8 Queens Parade, Bath; The Surgery, 11 Hayes Lane, Staple Hill; The Surgery, 13 Fallodon Way, Henleaze; The Surgery, 14 Overnhill Road, Staple Hill; The Surgery, 18 Fouracre Road, Downend; The Surgery, 24 Monks Park Avenue, Horfield; The Surgery, 37 West View Road, Keynsham; The Surgery, 38–42 Bradley Road, Patchway; The Surgery, 40 Parsonage Street, Dursley; The Surgery, 42 The Street, Uley, Dursley; The Surgery, 43 Gloucester Road, Filton; The Surgery, 43 Nevil Road, Bishopston; The Surgery, 58 Pembroke Road, Clifton; The Surgery, 60 Falcondale Road, Westbury-on-Trym; The Surgery, 111 Pembroke Road, Clifton; The Surgery, 232 Milton Road, Weston-super-Mare; The Surgery, 269 Stapleton Road, Easton; The Surgery, 521 Filton Avenue, Northville; The Surgery, Abbotswood, Yate; The Surgery, Coronation Road, Downend; The Surgery, Culverhay, Wotton-under-Edge; The Surgery, Mount Pleasant Park, Caldicot; The Surgery, Northwick Road, Pilning; The Surgery, St Mary Street, Thornbury; The Surgery, Sundays Hill, Lower Almondsbury; The Surgery, Sunnyside Road, Clevedon; The Surgery, Wellington Road, Yate; Thornbury Health Centre; Vauxhall Surgery, Tutshill, Chepstow; Wells City Practice, Wells; Wells Health Centre Practice; Whitchurch Health Centre; Whiteladies Family Practice, Clifton; Whiteladies Medical Centre, Clifton; Whitney Mead, Frampton Cotterell; William Budd Health Centre, Knowle West; Winscombe New Surgery; Wrington Vale Medical Practice, Wrington; Yatton Family Practice.

Author information

Authors and Affiliations

  1. University of Bristol Division of Transplantation Sciences, Bristol, UK

    C Donaldson, V Laundy, H Horsley, C Barron, B Bradley & J Hows

  2. Department of Women's Health Services, Southmead Hospital, Bristol, UK

    R Buchanan & J Webster

  3. National Blood Service, Bristol Centre, Bristol, UK

    N Anderson

Authors
  1. C Donaldson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Buchanan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J Webster
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V Laundy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H Horsley
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Barron
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. B Bradley
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J Hows
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Donaldson, C., Buchanan, R., Webster, J. et al. Development of a district Cord Blood Bank: a model for cord blood banking in the National Health Service. Bone Marrow Transplant 25, 899–905 (2000). https://doi.org/10.1038/sj.bmt.1702332

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702332

Keywords

Search

Advanced search

Quick links