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Lymphomas

Epstein–Barr virus and Hodgkin’s disease: further evidence for the three disease hypothesis

Leukemia volume 12, pages 1272–1276 (1998)Cite this article

Abstract

The epidemiology of Hodgkin’s disease suggests that it is a heterogeneous condition comprising more than one disease entity. The Epstein–Barr virus (EBV) is present in the Reed–Sternberg cells of a proportion of cases and is likely to play a role in the pathogenesis of these cases. In this study we show that EBV association rates vary with age at diagnosis. We suggest that Hodgkin’s disease can be divided into three disease entities on the basis of EBV association and age, thereby providing biological support for the multiple aetiology hypothesis proposed by MacMahon (Cancer Res 1966; 26: 1189–1290).

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Authors and Affiliations

  1. Department of Veterinary Pathology, LRF Virus Centre, University of Glasgow, Glasgow, UK

    AA Armstrong & RF Jarrett

  2. Department of Public Health Sciences, Edinburgh University Medical School, Edinburgh, UK

    FE Alexander

  3. LRF Centre for Clinical Epidemiology, University of Leeds, Leeds, UK

    R Cartwright & E Kane

  4. Division of Pathology, School of Pathological Sciences, The Royal Victoria Infirmary, Newcastle Upon Tyne, UK

    B Angus

  5. Department of Pathology, Edinburgh University Medical School, Edinburgh, UK

    AS Krajewski

  6. Department of Pathology, University of Southampton Medical School, Southampton, UK

    DH Wright

  7. University Department of Pathology, Western Infirmary, Glasgow, UK

    I Brown

  8. University Department of Pathology, Royal Infirmary, Glasgow, UK

    F Lee

Authors
  1. AA Armstrong
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  2. FE Alexander
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  3. R Cartwright
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  4. B Angus
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  5. AS Krajewski
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  6. DH Wright
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  7. I Brown
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  8. F Lee
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  9. E Kane
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  10. RF Jarrett
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Armstrong, A., Alexander, F., Cartwright, R. et al. Epstein–Barr virus and Hodgkin’s disease: further evidence for the three disease hypothesis. Leukemia 12, 1272–1276 (1998). https://doi.org/10.1038/sj.leu.2401097

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  • DOI: https://doi.org/10.1038/sj.leu.2401097

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