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IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr

Leukemia volume 17, pages 260–266 (2003)Cite this article

Abstract

IMGT, the international ImMunoGeneTics database® (http://imgt.cines.fr), is a high-quality integrated information system specializing in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complex (MHC) of human and other vertebrates, created in 1989, by LIGM, at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT includes several databases (IMGT/LIGM-DB, IMGT/3Dstructure-DB, IMGT/HLA-DB), Web resources (‘IMGT Marie-Paule page’) and interactive tools (IMGT/V-QUEST, IMGT/JunctionAnalysis). IMGT expertly annotated data and tools described in this paper are particularly useful for the analysis of the IG and TR rearrangements in leukemia, lymphoma and myeloma, and in translocations involving the antigen receptor loci. IMGT is freely available at http://imgt.cines.fr.

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References

  1. Lefranc, M-P & Lefranc, G The Immunoglobulin FactsBook, Academic Press: London (2001).

    Google Scholar 

  2. Lefranc, M-P & Lefranc, G The T Cell Receptor FactsBook, Academic Press: London (2001).

    Google Scholar 

  3. Stoesser, G, Baker, W, Van den Broek, A, Camon, E, Garcia-Pastor, M, Kanz, C, Kulikova, T, Lombard, V, Lopez, R, Parkinson, H, Redaschi, N, Sterk, P, Stoehr, P & Tuli, M-A The EMBL nucleotide sequence database. Nucleic Acids Res, (2001). 29, 17–21.

    Article  CAS  Google Scholar 

  4. Benson, DA, Karsch-Mizrachi, I, Lipman, D, Ostell, J, Rapp, BA & Wheeler, DL GenBank. Nucleic Acids Res, (2000). 28, 15–18.

    Article  CAS  Google Scholar 

  5. Tateno, Y, Miyazaki, S, Ota, M, Sugawara, H & Gojobori, T DNA Data Bank of Japan (DDBJ) in collaboration with mass sequencing teams. Nucleic Acids Res, (2000). 28, 24–26.

    Article  CAS  Google Scholar 

  6. Lefranc, M-P IMGT, the international ImMunoGeneTics database. Nucleic Acids Res, (2001). 29, 207–209.

    Article  CAS  Google Scholar 

  7. Giudicelli, V, Chaume, D, Bodmer, J, Müller, W, Busin, C, Marsh, S, Bontrop, R, Lemaitre, M, Malik, & Lefranc, M-P IMGT, the international ImMunoGeneTics database. Nucleic Acids Res, (1997). 25, 206–211.

    Article  CAS  Google Scholar 

  8. Lefranc, M-P, Giudicelli, V, Busin, C, Bodmer, J, Müller, W, Bontrop, R, Lemaitre, M, Malik, A & Chaume, D IMGT, the international ImMunoGeneTics database. Nucleic Acids Res, (1998). 26, 297–303.

    Article  CAS  Google Scholar 

  9. Lefranc, M-P, Giudicelli, V, Ginestoux, C, Bodmer, J, Müller, W, Bontrop, R, Lemaitre, M, Malik, A, Barbié, V & Chaume, D IMGT, the international ImMunoGeneTics database. Nucleic Acids Res, (1999). 27, 209–212.

    Article  CAS  Google Scholar 

  10. Ruiz, M, Giudicelli, V, Ginestoux, C, Stoehr, P, Robinson, J, Bodmer, J, Marsh, SG, Bontrop, R, Lemaitre, M, Lefranc, G, Chaume, D & Lefranc, M-P IMGT, the international ImMunoGeneTics database. Nucleic Acids Res, (2000). 28, 219–221.

    Article  CAS  Google Scholar 

  11. Ruiz, M & Lefranc, M-P IMGT gene identification and Colliers de Perles of human immunoglobulin with known 3D structures. Immunogenetics DOI 10.1007/s00251-001-0408-6. Immunogenetics, (2002). 53, 857–883.

    Article  CAS  Google Scholar 

  12. Robinson, J, Malik, A, Parham, P, Bodmer, JG & Marsh, SGE IMGT/HLA Database – a sequence database for the human major histocompatibility complex. Tissue Antigens, (2000). 55, 280–287.

    Article  CAS  Google Scholar 

  13. Giudicelli, V & Lefranc, M-P Ontology for Immunogenetics: IMGT-ONTOLOGY. Bioinformatics, (1999). 12, 1047–1054.

    Article  Google Scholar 

  14. Lefranc, M-P Nomenclature of the human immunoglobulin genes. Current Protocols in Immunology, J Wiley and Sons: New York (2000). Suppl. 40, A.1P.1–A.1P.37.

    Google Scholar 

  15. Lefranc, M-P Nomenclature of the human T cell Receptor genes. Current Protocols in Immunology, J Wiley and Sons: New York, USA (2000). Suppl. 40, A.1O.1–A.1O.23.

    Google Scholar 

  16. Lefranc, M-P Locus maps and genomic repertoire of the human Ig genes. Immunologist, (2000). 8, 80–87.

    CAS  Google Scholar 

  17. Lefranc, M-P Locus maps and genomic repertoire of the human T-cell receptor genes. Immunologist, (2000). 8, 72–79.

    CAS  Google Scholar 

  18. Lefranc, M-P Nomenclature of the human immunoglobulin heavy (IGH) genes. Exp Clin Immunogenet, (2001). 18, 100–116.

    Article  CAS  Google Scholar 

  19. Lefranc, M-P Nomenclature of the human immunoglobulin kappa (IGK) genes. Exp Clin Immunogenet, (2001). 18, 161–174.

    Article  CAS  Google Scholar 

  20. Lefranc, M-P Nomenclature of the human immunoglobulin lambda (IGL) genes. Exp Clin Immunogenet, (2001). 18, 242–254.

    Article  CAS  Google Scholar 

  21. Lefranc, M-P IMGT (ImMunoGeneTics) Locus on Focus. A new section of experimental and clinical immunogenetics. Exp Clin Immunogenet, (1998). 15, 1–7.

    Article  CAS  Google Scholar 

  22. Pallarès, N, Frippiat, JP, Giudicelli, V & Lefranc, M-P The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments. Exp Clin Immunogenet, (1998). 15, 8–18.

    Article  Google Scholar 

  23. Barbié, V & Lefranc, M-P The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments. Exp Clin Immunogenet, (1998). 15, 171–183.

    Article  Google Scholar 

  24. Pallarès, N, Lefebvre, S, Contet, V, Matsuda, F & Lefranc, M-P The human immunoglobulin heavy variable (IGHV) genes. Exp Clin Immunogenet, (1999). 16, 36–60.

    Article  Google Scholar 

  25. Ruiz, M, Pallarès, N, Contet, V, Barbié, V & Lefranc, M-P The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments. Exp Clin Immunogenet, (1999). 16, 173–184.

    Article  CAS  Google Scholar 

  26. Folch, G & Lefranc, M-P The human T cell receptor beta variable (TRBV) genes. Exp Clin Immunogenet, (2000). 17, 42–54.

    Article  CAS  Google Scholar 

  27. Scaviner, D & Lefranc, M-P The human T cell receptor alpha variable (TRAV) genes. Exp Clin Immunogenet, (2000). 17, 83–96.

    Article  CAS  Google Scholar 

  28. Scaviner, D & Lefranc, M-P The human T cell receptor alpha joining (TRAJ) genes. Exp Clin Immunogenet, (2000). 17, 97–106.

    Article  CAS  Google Scholar 

  29. Folch, G & Lefranc, M-P The human T cell receptor beta diversity (TRBD) and beta joining (TRBJ) genes. Exp Clin Immunogenet, (2000). 17, 107–114.

    Article  CAS  Google Scholar 

  30. Scaviner, D, Barbié, V, Ruiz, M & Lefranc, M-P Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions. Exp Clin Immunogenet, (1999). 16, 234–240.

    Article  CAS  Google Scholar 

  31. Folch, G, Scaviner, D, Contet, V & Lefranc, M-P Protein displays of the human T cell receptor alpha, beta, gamma and delta variable and joining regions. Exp Clin Immunogenet, (2000). 17, 205–215.

    Article  CAS  Google Scholar 

  32. Lefranc, M-P Unique database numbering system for immunogenetic analysis. Immunol Today, (1997). 18, 509

    Article  CAS  Google Scholar 

  33. Lefranc, M-P The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains. Immunologist, (1999). 7, 132–136.

    CAS  Google Scholar 

  34. Kabat, EA, Wu, TT, Perry, HM, Gottesman, KS & Foeller, C Sequences of Proteins of Immunological Interest, National Institute of Health Publications: Washington DC (1991). 91–3242.

    Google Scholar 

  35. Satow, Y, Cohen, GH, Padlan, EA & Davies, DR Phosphocholine binding immunoglobulin Fab McPC603. J Mol Biol, (1986). 190, 593–604.

    Article  CAS  Google Scholar 

  36. Chothia, C & Lesk, AM Canonical structures for the hypervariable regions of immunoglobulins. J Mol Biol, (1987). 196, 901–917.

    Article  CAS  Google Scholar 

  37. Lefranc, M-P Web sites of Interest to immunologists. Current Protocols in Immunology, J Wiley and Sons: New York (2000). A.1J.1–A.1J.33.

    Google Scholar 

  38. Giudicelli, V, Chaume, D & Lefranc, M-P IMGT/LIGM-DB: A systematized approach for ImMunoGeneTics database coherence and data distribution improvement. Proceedings of the Sixth International Conference on Intelligent Systems for Molecular Biology, ISBM-98. (1998). 59–68.

  39. Giudicelli, V, Chaume, D, Mennessier, G, Althaus, HH, Mller, W, Bodmer, J, Malik, A & Lefranc, M-P IMGT, the international ImMunoGeneTics database: a new Design for Immunogenetics Data Access. In: Cesnik B et al (eds). Proceedings of the Ninth World Congress on Medical Informatics, MEDINFO’ 98, IOS Press: Amsterdam (1998). 351–355.

    Google Scholar 

  40. Lefranc, M-P IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immmunogenetics and immunology. Dev Comp Immunol, (in press)

  41. Eckert, C, Landt, O, Taube, T, Seeger, K, Beyermann, B, Proba, J & Henze, G Potential of LightCycler technology for quantification of minimal residual disease in childhood acute lymphoblastic leukemia. Leukemia, (2000). 14, 316–323.

    Article  CAS  Google Scholar 

  42. Delabesse, E, Burtin, ML, Millien, C, Madonik, A, Arnulf, B, Beldjord, K, Valensi, F & Macintyre, EA Rapid, multifluorescent TCRG Vgamma and Jgamma typing: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations. Leukemia, (2000). 14, 1143–1152.

    Article  CAS  Google Scholar 

  43. Szczepanski, T, Langerak, AW, Willemse, MJ, Wolvers-Tettero, ILM, van Wering, ER & van Dongen, JJM T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia reflect ‘end-stage’ recombinations: implications for minimal residual disease monitoring. Leukemia, (2000). 14, 1208–1214.

    Article  CAS  Google Scholar 

  44. Bruggemann, M, Droese, J, Bolz, I, Luth, P, Pott, C, von Neuhoff, N, Scheuering, U & Kneba, M Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR. Leukemia, (2000). 14, 1419–1425.

    Article  CAS  Google Scholar 

  45. Verhagen, OJHM, Willemse, MJ, Breunis, WB, Wijkhuijs, AJM, Jacobs, DCH, Joosten, SA, van Wering, ER, van Dongen, JJM & van der Schoot, CE Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia. Leukemia, (2000). 14, 1426–1435.

    Article  CAS  Google Scholar 

  46. De Haas, V, Verhagen, OJ, von dem Borne, AE, Kroes, W, van den Berg, H & van der Schoot, CE Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy. Leukemia, (2001). 15, 134–140.

    Article  CAS  Google Scholar 

  47. Szczepanski, T, Willemse, MJ, van Wering, ER, Weerden, JF, Kamps, WA & van Dongen, JJM Precursor-B-ALL with DH-JH gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14. Leukemia, (2001). 15, 1415–1423.

    Article  CAS  Google Scholar 

  48. Moreira, I, Papaioannou, M, Mortuza, FY, Gameiro, P, Palmisano, GL, Harrison, CJ, Prentice, HG, Mehta, AB, Hoffbrand, AV & Foroni, L Heterogeneity of VH-JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL. Leukemia, (2001). 15, 1527–1536.

    Article  CAS  Google Scholar 

  49. Boeckx, N, Willemse, MJ, Szczepanski, T, van Der Velden, VHJ, Langerak, AW, Vandekerckhove, P & van Dongen, JJM Fusion gene transcripts and Ig/TCR gene rearrangements are complementary but infrequent targets for PCR-based detection of minimal residual disease in acute myeloid leukemia. Leukemia, (2002). 16, 368–375.

    Article  CAS  Google Scholar 

  50. Van der Velden, VHJ, Wijkhuijs, JM, Jacobs, DCH, van Wering, ER & van Dongen, JJM T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis. Leukemia, (2002). 16, (in press)

  51. Van der Velden, VHJ, Willemse, MJ, van der Schoot, CE, van Wering, ER & van Dongen, JJM Immunoglobulin kappa deleting element rearrangements in precursor–B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR. Leukemia, (2002). 16, (in press)

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Acknowledgements

I thank Véronique Giudicelli, Denys Chaume and Gérard Lefranc for helpful discussion, Nora Bonnet for typing the manuscript. I am deeply grateful to the IMGT team for its expertise and constant motivation. IMGT is funded by the European Union's 5th PCRDT programme (QLG2-2000-01287), the CNRS (Centre National de la Recherche Scientifique), the Ministère de l’Education Nationale, and the Ministère de la Recherche. Subventions have been received from ARC (Association pour la Recherche sur le Cancer), and the Région Languedoc-Roussillon.

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  1. Laboratoire d'ImmunoGénétique Moléculaire, LIGM, Université Montpellier II, UPR CNRS 1142, Institut de Génétique Humaine, IGH, Montpellier, France

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Lefranc, MP. IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr. Leukemia 17, 260–266 (2003). https://doi.org/10.1038/sj.leu.2402637

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