Gastroenterology

Gastroenterology

Volume 112, Issue 2, February 1997, Pages 561-566
Gastroenterology

Multiple hyperplastic polyps in the stomach: Evidence for clonality and neoplastic potential

https://doi.org/10.1053/gast.1997.v112.pm9024310Get rights and content

Abstract

The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This report describes a patient diagnosed with three concurrent hyperplastic gastric polyps that were studied for genetic alterations. The polyps were investigated for alterations in the K-ras oncogene and the p53 tumor suppressor gene and for p21WAF1/Cip1 and MDM2 protein overexpression. In addition, loss of heterozygosity at several loci that are frequently involved in human cancer was analyzed, microsatellite instability, a hallmark of the "mutator" phenotype, was determined, and Epstein-Barr virus infection was investigated. All separate areas from the three independent polyps harbored the same activating point mutation in codon 12 of the K-ras oncogene, indicating a clonal origin. DNA sequence alterations in p53 were not found, although high p53 protein levels could be shown by immunohistochemistry in areas of carcinoma within the largest polyp. No alterations in any of the other molecular markers were observed. The results strongly favor a clonal origin of the three independent gastric polyps and support the notion that these hyperplastic polyps may carry a risk for malignancy.

(Gastroenterology 1997 Feb;112(2):561-6)

References (0)

Cited by (47)

  • Computed Tomography Imaging of Non-Neoplastic and Neoplastic Benign Gastric Disease

    2019, Current Problems in Diagnostic Radiology
    Citation Excerpt :

    Between 1% and 20% of the hyperplastic polyps are believed to harbor foci of dysplasia. Risk of malignancy increases with size greater than 1 cm.49 Fundic gland polyps are mostly sporadic and common in the western world where proton pump inhibitor use is common and H. pylori is less prevalent.

  • Mutational analysis by next generation sequencing of gastric type dysplasia occurring in hyperplastic polyps of the stomach. Mutations in gastric hyperplastic polyps

    2015, Experimental and Molecular Pathology
    Citation Excerpt :

    Increased p53 immunoreactivity has been reported in dysplasia and adenocarcinoma, but not in the non-dysplastic hyperplastic areas of the polyp (Zea-Iriarte et al., 1996; Terada, 2011; Yao et al., 2002; Murakami et al., 2001; Dijkhuizen et al., 1997). Data from earlier studies showed that chromosomal alterations and rare cases of KRAS mutations have been implicated in the development of dysplasia in GHP, while alterations in the TP53 gene were the most common abnormality and a late event in GHP transformation (Weiss et al., 2003; Murakami et al., 2001; Dijkhuizen et al., 1997). However, thorough characterization of genomic alterations driving the dysplasia–carcinoma sequence in GHP is lacking.

  • Gastric polyps: Pathology and genetics

    2006, Annales de Pathologie
  • Gastric hyperplastic polyps: a narrative review

    2023, Digestive Medicine Research
View all citing articles on Scopus
View full text