Cytokines modulate fibroblast phenotype and epithelial-stroma interactions in rat intestine
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Signals and forces shaping organogenesis of the small intestine
2019, Current Topics in Developmental BiologyCitation Excerpt :When 5.5-day chick gizzard endoderm (or E14 rat intestinal endoderm) is wrapped by a confluent sheet of pericryptal fibroblasts isolated from the intestine of postnatal rats and grafted into the chick coelomic cavity, the endoderm develops villi and expresses intestinal enzymes (Fritsch, Simon-Assmann, Kedinger, & Evans, 1997; Haffen, Lacroix, Kedinger, & Simon-Assmann, 1983). Some grafts also exhibited surrounding smooth muscle layers and express biochemical markers of intestine (Fritsch et al., 1997). Strikingly, a rat intestinal cell line, IEC-17, can be substituted for the endoderm; when wrapped with E14 rat intestinal mesenchyme and grafted under the rat kidney capsule, 10% of the grafts formed villi and exhibited an epithelium with typical intestinal cell types and enzymatic signatures of the intestine, with a well-developed surrounding muscular layer (Kedinger et al., 1986).
Marine natural products for multi-targeted cancer treatment: A future insight
2018, Biomedicine and PharmacotherapyIntestinal Regeneration. The Stem Cell Approach.
2014, Regenerative Medicine Applications in Organ TransplantationIntestinal stromal cells in mucosal immunity and homeostasis
2013, Mucosal ImmunologyMucosal Restitution and Repair
2012, Physiology of the Gastrointestinal Tract, Two Volume SetMucosal Restitution and Repair
2012, Physiology of the Gastrointestinal Tract