Original ContributionsExpression of CD10 by stromal cells during colorectal tumor development*,**
Section snippets
Patients and tumor specimens
The subjects of this study were 169 Japanese patients who underwent colectomy at Tokyo Medical University Hospital, with 10 normal colorectal tissue samples used as controls. The blocks of formalin-fixed, paraffin-embedded tissue from these patients were retrieved from the Diagnostic Pathology Division. All pathologic diagnoses were confirmed independently by 3 pathologists reviewing hematoxylin and eosin (H&E)-stained sections. Briefly, adenomas were divided into 3 grades of dysplasia
CD10 expression in the stromal cells
Expression of CD10 by the tumor cells was not examined in this study. There was no expression of CD10 in the stromal cells of the 10 normal colorectal tissue samples. CD10 was positive in 88 of 169 colorectal tumors (52.1%). CD10-positive stromal cells appeared adjacent to the tumor cells and surrounded the neoplastic tubules or glands in 16 of 73 adenomas (21.9%) with mild or moderate dysplasia. Stromal CD10 was positive in 12 of 17 adenomas (70.6%) with severe dysplasia, in 10 of 16
Discussion
This study demonstrated that CD10 is frequently expressed by the stromal cells within adenomas with severe dysplasia grade and carcinomas. CD10 is expressed by the tumor cells in different organs13, 14, 15 and is associated with differentiation and growth of tumor cells.16, 17 Few studies have demonstrated CD10 expression by tumor-associated stromal cells. Ours is the first study that has investigated CD10 expression by the stromal cells within colorectal tumors. According to the theory of the
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Supported in part by Grants in Aid for Cancer Research and for the second-term Comprehensive Strategy for Cancer Control from the Ministry of Health, Labour, and Welfare.
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Address correspondence and reprint requests to Kiyoshi Mukai, MD, Department of Pathology, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku, Tokyo, 160-8402 Japan.