HPV-related cancer susceptibility and p53 codon 72 polymorphism

Authors

  • Anna C. Gustafsson
  • Zhongmin Guo
  • Xinrong Hu
  • Afshin Ahmadian
  • Bertha Brodin
  • Anna Nilsson
  • Jan Pontén
  • Fredrik Pontén
  • Joakim Lundeberg

DOI:

https://doi.org/10.1080/00015550152384272

Abstract

Conflicting results regarding the association of a polymorphism at codon 72 of the p53 tumour suppressor gene and susceptibility to develop human papilloma virus (HPV)-associated cervical cancer have been published over the last year, implicating differences in ethnic background, sample origin, sample size and/or detection assay. The material for this study was collected in the identical geographical region as for 2 previous reports with contradictory results regarding the association of codon 72 genotype with squamous cell cancer (SCC). We have used an alternative detection assay, based on pyrosequencing technology, that interrogates the variable position by the accuracy of DNA polymerase. In addition to cervical clinical specimens from SCC, HPV16- and HPV18-infected adenocarcinoma cases as well as cervical intraepithelial neoplasia (CIN) were investigated. No significant association was found between p53 codon 72 genotype and the risk to develop adenocarcinoma, SCC or CIN in the Swedish population.

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Published

2001-03-20

How to Cite

Gustafsson, A. C., Guo, Z., Hu, X., Ahmadian, A., Brodin, B., Nilsson, A., Pontén, J., Pontén, F., & Lundeberg, J. (2001). HPV-related cancer susceptibility and p53 codon 72 polymorphism. Acta Dermato-Venereologica, 81(2), 125–129. https://doi.org/10.1080/00015550152384272

Issue

Vol. 81 No. 2 (2001)

Section

Articles

License

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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