A case of keratin-positive acute myeloid leukemia: a possible role for cytokeratin 19 as a specific epithelial marker

doi:10.1080/003130200104312

Pathology

Volume 32, Issue 2, 2000, Pages 98-101

https://doi.org/10.1080/003130200104312 Get rights and content

Summary

A patient with relapsed acute myelomonocytic leukemia (AML, FAB M4) developed skin infiltration by leukemic blasts. On immunochemistry, the blasts showed “dot” positive cytoplasmic staining for cytokeratins AE1/AE3 and CAM 5.2, resembling the pattern seen in Merkel cell carcinoma of skin. However, the blasts were positive for myeloid markers and negative for cytokeratin 19 and chromogranin. Aberrant immunochemical staining can lead to misdiagnosis unless a panel of antibodies of known specificity is used in tumor diagnosis, and the clinical context is taken into account. The possible role of cytokeratin 19 as a more specific marker for epithelia than keratin cocktails is discussed.

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A case of keratin-positive acute myeloid leukemia: a possible role for cytokeratin 19 as a specific epithelial marker

Summary

Differentiation

Keratin gene expression in non-epithelial tissues. Detection with polymerase chain reaction

Am J Pathol

Keratin immunohistochemistry: update of applications and pitfalls

Pathol Annu

Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunohistochemical study

Virchows Arch

Increased numbers of cytokeratin-positive interstitial reticulum cells (CIRC) in reactive, inflammatory and neoplastic lymphadenopathies: hyperplasia or induced expression?

Virchows Arch

Gastric large cell lymphoma expressing cytokeratin but no leucocyte common antigen. A diagnostic dilemma

Am J Clin Pathol

Cytokeratin in anaplastic large cell lymphoma

Mod Pathol

Cutaneous lymphoma-simulating Merkel cell carcinoma: molecular genetic demonstration of a clonal disease with divergent immunophenotypes

Mod Pathol

Cytokeratin-positive large-cell lymphomas of B-cell lineage. A study of five phenotypically unusual cases verified by polymerase chain reaction

Am J Surg Pathol

Common acute lymphoblastic leukaemia-lymphoma expressing cytokeratin: a case report

Virchows Arch

Precursor B-lymphoblastic lymphoma presenting as a solitary bone tumor and mimicking Ewing’s sarcoma. A report of four cases and review of the literature

Am J Surg Pathol

Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin’s lymphomas

Am J Pathol

Cytokeratin positive T cell malignant lymphoma

J Clin Pathol