Chest
Volume 106, Issue 6, December 1994, Pages 1887-1889
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Selected Reports: Articles
Human Papilloma Virus Associated With Solitary Squamous Papilloma Complicated by Bronchiectasis and Bronchial Stenosis

https://doi.org/10.1378/chest.106.6.1887Get rights and content

A 28-year-old man presented with recurrent pneumonias for 6 years. Chest radiograph and computed tomography showed localized bronchiectasis of the anterior segment of the left upper lobe. Bronchoscopy showed bronchial stenosis without an endobronchial lesion. After 6 weeks of antibiotic treatment, the patient had a recurrent pneumonia and underwent left upper lobectomy that showed a solitary squamous papilloma. In situ hybridization studies of the papilloma were reactive for human papilloma virus subtypes 6/11.

Section snippets

CASE REPORT

A 28-year-old white man presented for evaluation of recurrent left upper lobe pneumonia. Over a 6-year period, he had seven pneumonias requiring antibiotic therapy. He complained of purulent sputum production, dyspnea, and several episodes of hemoptysis. The patient denied any history of decreased appetite, weight loss, asthma, sinusitis, or tuberculosis exposure. He also denied tobacco or illicit drug use. The patient had no history of foreign travel, and he was not taking any medications.

DISCUSSION

Bronchial papillomas have three distinct clinical presentations: multiple papillomas, inflammatory polyps, or solitary papillomas.1 Multiple papillomas are the most common and occur in the larynx and lower respiratory tract of children, although they have been described in adults.2 They are associated with the HPV and are thought to be secondary to aspiration of the virus in utero or during parturition in a mother infected with genital warts.3,4 Inflammatory papillomas arise in chronically

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