Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung
Noriharu SHIJUBOYuji INOUEMichio HIRASAWATomofumi IGARASHIMasaki MORIAkihiro MATSUURAToshimitsu UEDEAkira SUZUKI
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1992 Volume 31 Issue 2 Pages 277-280

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Abstract

We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.
(Internal Medicine 31 : 277-280, 1992)

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© The Japanese Society of Internal Medicine
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