Abstract
Neonates mount poor immune responses, and it has been assumed that neonatal T cells differ qualitatively from adult T cells. Here, Becky Adkins discusses this issue in the light of recent data indicating that T cells in neonates are developmentally mature in their capacity to mount protective Th1-type and cytotoxic T lymphocyte responses.
MeSH terms
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Adult
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Animals
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Animals, Newborn
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B-Lymphocytes / immunology
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Cell Differentiation
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Cytokines / biosynthesis
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Fetal Blood / cytology
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Fetal Blood / immunology
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Humans
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In Vitro Techniques
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Infant, Newborn / immunology*
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Mice
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Models, Biological
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes, Cytotoxic / cytology
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T-Lymphocytes, Cytotoxic / immunology
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Th1 Cells / cytology
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Th1 Cells / immunology