Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53

H Y Ngan; V W Liu; S S Liu

doi:10.1038/sj.bjc.6690606

Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53

Br J Cancer. 1999 Aug;80(11):1828-9. doi: 10.1038/sj.bjc.6690606.

Authors

H Y Ngan¹, V W Liu, S S Liu

Affiliation

¹ Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong.

Abstract

Homozygous arginine at codon 72 (HA72) of p53 was found in 22% of normal cervices and 30.0% of cervical cancers and no significant difference was detected between normal and cervical cancer with or without HPV 16/18. There was no correlation between HA72 and risk of cervical cancer in Chinese.

MeSH terms

Arginine*
Asian People / genetics*
China / ethnology
Female
Genes, p53*
Homozygote*
Hong Kong / epidemiology
Humans
Incidence
Papillomaviridae / isolation & purification
Polymerase Chain Reaction
Polymorphism, Genetic*
Risk Factors
Tumor Suppressor Protein p53 / genetics*
Uterine Cervical Neoplasms / epidemiology*
Uterine Cervical Neoplasms / genetics*
Uterine Cervical Neoplasms / virology

Substances

Tumor Suppressor Protein p53
Arginine