Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine

Lancet. 1999 Oct 30;354(9189):1524-5. doi: 10.1016/S0140-6736(99)04265-8.

Abstract

Cancer-screening tests for internal organs are severely constrained by low specificity or sensitivity, cost, and morbidity. We report a non-invasive immunofluorometric assay for detection of urothelial cancers based on ectopic expression of the DNA replication protein Mcm5.

Publication types

  • Letter

MeSH terms

  • Biomarkers, Tumor
  • Carcinoma, Transitional Cell / pathology*
  • Cell Cycle Proteins / urine*
  • Fluorescent Antibody Technique, Indirect*
  • Humans
  • Sensitivity and Specificity
  • Urinary Bladder Neoplasms / pathology*

Substances

  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • MCM5 protein, human