Abstract
Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / biosynthesis*
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Child, Preschool
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Gambia
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Humans
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Immunity, Mucosal
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Immunization Schedule
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Immunoglobulin A, Secretory / biosynthesis*
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Immunoglobulin G / biosynthesis*
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Immunoglobulin G / blood
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Immunologic Memory
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Meningococcal Vaccines / administration & dosage*
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Neisseria meningitidis / immunology*
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Polysaccharides, Bacterial / administration & dosage
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Polysaccharides, Bacterial / immunology*
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Saliva / immunology*
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Vaccines, Conjugate / administration & dosage
Substances
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Antibodies, Bacterial
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Immunoglobulin A, Secretory
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Immunoglobulin G
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Meningococcal Vaccines
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Polysaccharides, Bacterial
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Vaccines, Conjugate