Abstract
Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Differentiation / genetics*
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Core Binding Factor Alpha 1 Subunit
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Gene Expression Regulation, Developmental*
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Humans
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Neoplasm Proteins*
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Osteoblasts / cytology*
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Osteogenesis / genetics*
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Transcription Factors / chemistry
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Transcription Factors / genetics*
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Transcription Factors / metabolism*
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Transcription, Genetic
Substances
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Core Binding Factor Alpha 1 Subunit
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Neoplasm Proteins
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Transcription Factors