Abstract
The in vitro activity of ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin against strains of Mycobacterium tuberculosis was studied. Moxifloxacin and levofloxacin showed the greatest activity having an MIC(90) of 1 mg/l. The MIC(90) for ofloxacin was 2 mg/l and for ciprofloxacin 4 mg/l. Further studies should be made to determine the role played by these compounds in the treatment of tuberculosis.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Antitubercular Agents / pharmacology*
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Aza Compounds*
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Ciprofloxacin / pharmacology
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Dose-Response Relationship, Drug
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Fluoroquinolones*
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Humans
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Levofloxacin
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Microbial Sensitivity Tests
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Moxifloxacin
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Mycobacterium tuberculosis / drug effects*
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Ofloxacin / pharmacology
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Quinolines*
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Spain
Substances
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Anti-Infective Agents
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Antitubercular Agents
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Aza Compounds
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Fluoroquinolones
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Quinolines
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Ciprofloxacin
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Levofloxacin
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Ofloxacin
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Moxifloxacin