Immunoreactivity for P-170 glycoprotein in malignant mesothelioma and in non-neoplastic mesothelium of the pleura using the murine monoclonal antibody JSB-1

M Ramael; J van den Bossche; C Buysse; J van Meerbeeck; K Segers; P Vermeire; E van Marck

doi:10.1002/path.1711670103

Immunoreactivity for P-170 glycoprotein in malignant mesothelioma and in non-neoplastic mesothelium of the pleura using the murine monoclonal antibody JSB-1

J Pathol. 1992 May;167(1):5-8. doi: 10.1002/path.1711670103.

Authors

M Ramael¹, J van den Bossche, C Buysse, J van Meerbeeck, K Segers, P Vermeire, E van Marck

Affiliation

¹ Department of Pathology, University Hospital Antwerp, University of Antwerp, Belgium.

PMID: 1352542
DOI: 10.1002/path.1711670103

Abstract

The results of an immunohistochemical study of P-170 glycoprotein immunoreactivity in human non-neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using the murine monoclonal antibody JSB-1 are reported. The majority of malignant mesothelioma cases exhibited cytoplasmic and membrane immunoreactivity in neoplastic cells. These findings are highly significant when compared with the absence of immunoreactivity in normal mesothelium.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Antibodies, Monoclonal
Epithelium / chemistry*
Humans
Immunohistochemistry
Membrane Glycoproteins / analysis*
Mesothelioma / chemistry*
Mesothelioma / pathology
Mice
Neoplasm Proteins / analysis*
Pleural Neoplasms / chemistry*
Pleural Neoplasms / pathology

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antibodies, Monoclonal
Membrane Glycoproteins
Neoplasm Proteins