Cancer cell invasion and metastasis

Sci Am. 1992 Feb;266(2):54-9, 62-3. doi: 10.1038/scientificamerican0292-54.

Abstract

The most life-threatening aspect of cancer is the undetected spread of tumor cells throughout the body. Improved understanding of how these cells invade tissues is leading to new treatments.

MeSH terms

  • Basement Membrane / pathology
  • Blood Vessels / pathology
  • Cell Adhesion
  • Cell Movement
  • Extracellular Matrix / pathology
  • Genes, Tumor Suppressor
  • Humans
  • Lymphatic System / pathology
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / metabolism
  • Monomeric GTP-Binding Proteins*
  • NM23 Nucleoside Diphosphate Kinases
  • Neoplasm Metastasis* / diagnostic imaging
  • Neoplasm Metastasis* / genetics
  • Neoplasm Metastasis* / pathology
  • Neoplasm Proteins
  • Neoplastic Cells, Circulating
  • Neovascularization, Pathologic
  • Nucleoside-Diphosphate Kinase*
  • Proteins / genetics
  • Proteins / physiology
  • Radionuclide Imaging
  • Tissue Inhibitor of Metalloproteinase-2
  • Transcription Factors*

Substances

  • NM23 Nucleoside Diphosphate Kinases
  • Neoplasm Proteins
  • Proteins
  • Transcription Factors
  • Tissue Inhibitor of Metalloproteinase-2
  • Nucleoside-Diphosphate Kinase
  • Metalloendopeptidases
  • Monomeric GTP-Binding Proteins