At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

John M Kyriakis

doi:10.1186/1475-4924-2-26

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

J Biol. 2003;2(4):26. doi: 10.1186/1475-4924-2-26. Epub 2003 Oct 22.

Author

John M Kyriakis¹

Affiliation

¹ Molecular Cardiology Research Institute, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA. jkyriakis@tufts-nemc.org

Abstract

The tumor suppressor kinase LKB1 has been identified as a physiologic activator of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a possible molecular link between the regulation of metabolism and cell proliferation.

Publication types

Review

MeSH terms

AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases
Animals
Cell Growth Processes / physiology*
Cell Proliferation*
Genes, Tumor Suppressor / physiology*
Humans
Multienzyme Complexes / physiology*
Protein Serine-Threonine Kinases / physiology*

Substances

Multienzyme Complexes
Protein Serine-Threonine Kinases
STK11 protein, human
AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases