Abstract
One of the effects of oncogenic signaling appears to be differentiated recruitment of mRNA's to ribosomes. The mRNA's so affected frequently encode proteins involved in growth regulation cell-cell interaction. These functions are critical for both cancer and development, potentially suggesting that the normal role of differential translation may be during development. It is not known whether this effect is sufficient to induce cancer from cells with an initial non-neoplastic gene expression profile.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adaptor Proteins, Signal Transducing
-
Animals
-
Carrier Proteins / metabolism
-
Cell Communication
-
Cell Cycle Proteins
-
Enzyme Activation
-
Eukaryotic Initiation Factor-4E / metabolism
-
Gene Expression Regulation
-
Humans
-
MAP Kinase Signaling System*
-
Models, Biological
-
Neoplasms / pathology*
-
Neoplasms / therapy
-
Phosphatidylinositol 3-Kinases / metabolism
-
Phosphoproteins / metabolism
-
Phosphorylation
-
Protein Biosynthesis*
-
RNA, Messenger / metabolism
-
Ribosomal Protein S6 Kinases / metabolism*
-
Ribosomes / metabolism
-
Signal Transduction
Substances
-
Adaptor Proteins, Signal Transducing
-
Carrier Proteins
-
Cell Cycle Proteins
-
EIF4EBP1 protein, human
-
Eukaryotic Initiation Factor-4E
-
Phosphoproteins
-
RNA, Messenger
-
Ribosomal Protein S6 Kinases