Abstract
The genes and mechanisms that control programmed cell death are currently the subject of intense study. The bcl-2 gene, a repressor of lymphocyte death, is perhaps the best understood of the programmed cell death associated genes. Here, Stanley Korsmeyer provides a brief overview of bcl-2, concentrating on its roles in B- and T-cell development and in oncogenesis.
MeSH terms
-
Animals
-
B-Lymphocytes
-
Cell Death / genetics*
-
GTP-Binding Proteins / genetics*
-
Humans
-
Lymphocyte Activation
-
Lymphoma / genetics
-
Lymphoma / immunology
-
Mice
-
Mice, Transgenic
-
Proto-Oncogene Proteins / genetics*
-
Proto-Oncogene Proteins c-bcl-2
-
Repressor Proteins / genetics*
-
T-Lymphocytes
Substances
-
Proto-Oncogene Proteins
-
Proto-Oncogene Proteins c-bcl-2
-
Repressor Proteins
-
GTP-Binding Proteins