Abstract
The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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DNA Nucleotidyltransferases / genetics*
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Gene Rearrangement, T-Lymphocyte / genetics
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Genes, Immunoglobulin*
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Receptors, Antigen, T-Cell / genetics*
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Recombination, Genetic
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Substrate Specificity
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VDJ Recombinases
Substances
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Receptors, Antigen, T-Cell
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DNA Nucleotidyltransferases
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VDJ Recombinases