Abstract
High loads of human papillomavirus (HPV) 16 and HPV 18/45 increase the risk of developing invasive cervical carcinoma, revealing higher risk in percentiles of highest viral loads for HPV 16 (odds ratio (OR) 58.7, 95% confidence interval (CI) 21.9-151.4) compared to HPV 18/45 (OR 3.3, 95% CI 1.5-7.2). Thus, HPV load is a type-dependent risk marker for invasive carcinoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / virology
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DNA, Neoplasm / genetics
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Female
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Humans
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Middle Aged
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Neoplasm Invasiveness
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Odds Ratio
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Papillomaviridae / isolation & purification*
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Risk Factors
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Uterine Cervical Neoplasms / pathology*
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Uterine Cervical Neoplasms / virology
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Vaginal Smears
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Viral Load*