Abstract
Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actins / metabolism
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Animals
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Cell Movement
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Cytoskeleton / metabolism
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Gene Expression Regulation, Neoplastic / genetics
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Humans
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Mice
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Neoplasm Invasiveness / pathology
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Neoplasm Invasiveness / physiopathology*
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Neoplasms / diagnosis
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Neoplasms / genetics*
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Neoplasms / therapy
Substances
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Actins
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Biomarkers, Tumor
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Gp38 protein, mouse
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Membrane Glycoproteins
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PDPN protein, human