BMP6 orchestrates iron metabolism

Nat Genet. 2009 Apr;41(4):386-8. doi: 10.1038/ng0409-386.

Abstract

The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body's demands. Two new studies now identify BMP6 as the key endogenous regulator of hepcidin.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / metabolism*
  • Bone Morphogenetic Protein 4 / metabolism*
  • Bone Morphogenetic Protein 6 / metabolism*
  • Hemostasis
  • Hepcidins
  • Homeostasis
  • Humans
  • Iron / metabolism*
  • Mammals

Substances

  • Antimicrobial Cationic Peptides
  • BMP4 protein, human
  • BMP6 protein, human
  • Bone Morphogenetic Protein 4
  • Bone Morphogenetic Protein 6
  • HAMP protein, human
  • Hepcidins
  • Iron