Abstract
The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body's demands. Two new studies now identify BMP6 as the key endogenous regulator of hepcidin.
MeSH terms
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Animals
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Antimicrobial Cationic Peptides / metabolism*
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Bone Morphogenetic Protein 4 / metabolism*
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Bone Morphogenetic Protein 6 / metabolism*
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Hemostasis
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Hepcidins
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Homeostasis
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Humans
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Iron / metabolism*
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Mammals
Substances
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Antimicrobial Cationic Peptides
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BMP4 protein, human
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BMP6 protein, human
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Bone Morphogenetic Protein 4
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Bone Morphogenetic Protein 6
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HAMP protein, human
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Hepcidins
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Iron