Abstract
In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Carcinoma, Large Cell / complications*
-
Carcinoma, Large Cell / drug therapy
-
Carcinoma, Large Cell / metabolism*
-
Eosinophilia / diagnosis
-
Eosinophilia / etiology*
-
Fatal Outcome
-
Granulocyte Colony-Stimulating Factor / blood*
-
Humans
-
Lung Neoplasms / complications*
-
Lung Neoplasms / drug therapy
-
Lung Neoplasms / metabolism*
-
Male
-
Middle Aged
Substances
-
Granulocyte Colony-Stimulating Factor