Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation
Bull Exp Biol Med. 2012 Oct;153(6):878-81.
doi: 10.1007/s10517-012-1849-7.
[Article in
English,
Russian]
Affiliation
- 1 People's Friendship University of Russia, Moscow, Russia. kevsan@orc.ru
Abstract
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.
MeSH terms
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Antineoplastic Agents / pharmacology
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Breast Neoplasms / drug therapy
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Breast Neoplasms / enzymology
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Breast Neoplasms / genetics*
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Carcinoma / drug therapy
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Carcinoma / enzymology
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Carcinoma / genetics*
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Cell Line, Tumor
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Cisplatin / pharmacology
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Drug Resistance, Neoplasm / drug effects
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Drug Resistance, Neoplasm / genetics
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Female
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Gene Expression / drug effects
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Humans
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Leukemia, Erythroblastic, Acute / drug therapy
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Leukemia, Erythroblastic, Acute / enzymology
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Leukemia, Erythroblastic, Acute / genetics*
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / enzymology
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Ovarian Neoplasms / genetics*
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Oxidative Stress
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Peroxiredoxin III / genetics*
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Peroxiredoxin III / metabolism
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Peroxiredoxin VI / genetics*
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Peroxiredoxin VI / metabolism
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Peroxiredoxins / genetics*
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Peroxiredoxins / metabolism
Substances
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Antineoplastic Agents
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PRDX1 protein, human
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PRDX2 protein, human
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PRDX3 protein, human
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PRDX6 protein, human
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Peroxiredoxin III
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Peroxiredoxin VI
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Peroxiredoxins
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Cisplatin