Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

Affiliations

• ¹ Department of Pathology, University of Michigan, Ann Arbor, MI, 48104, USA.
• ² Division of Haematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
• ³ Programme in Neuroscience and Mental Health, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
• ⁴ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard, MS #43, Los Angeles, CA, 90027, USA.
• ⁵ Division of Anatomic Pathology, British Columbia Children's Hospital, 4500 Oak Street, Vancouver, BC, V6H 3N1, Canada.
• ⁶ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, V6T1Z3, BC, Canada.
• ⁷ Divisions of Neurology and Hematology and Oncology, Children's and Women's Health Centre of B.C, University of British Columbia, Vancouver, BC, V6H 3N1, Canada.
• ⁸ Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
• ⁹ Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ¹⁰ Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, 90027, USA.
• ¹¹ Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
• ¹² Department of Anatomic Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
• ¹³ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ¹⁴ Department of Pathology, New York University, New York, NY, USA.
• ¹⁵ Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
• ¹⁶ Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
• ¹⁷ Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
• ¹⁸ Department of Pathology and Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
• ¹⁹ Division of Hematology-Oncology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, QC, Canada.
• ²⁰ Division of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB, T2W3N2, Canada.
• ²¹ Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
• ²² Division of Pediatric Hematology/Oncology, Alberta Children's Hospital, Calgary, AB, T3B6A8, Canada.
• ²³ Division of Pediatric Hematology/Oncology, London Health Sciences Center, Children's Hospital, London, ON, N6A5A5, Canada.
• ²⁴ Department of Pediatrics and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
• ²⁵ Kingston General Hospital, Kingston, ON, Canada.
• ²⁶ Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
• ²⁷ Division of Hematology/Oncology, University Children Hospital of Basel (UKBB) and University of Basel, Basel, Switzerland.
• ²⁸ Department of Pediatrics, McGill University, Montreal, QC, H3Z2Z3, Canada.
• ²⁹ Department of Human Genetics, McGill University, Montreal, QC, H3Z2Z3, Canada.
• ³⁰ Division of Neonatal Pediatrics, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
• ³¹ German Cancer Consortium (DKTK), Heidelberg, Germany.
• ³² Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.
• ³³ Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
• ³⁴ Pediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
• ³⁵ Department of Neuropathology, German Cancer Research Center (DKFZ), University Hospital Heidelberg and CCU Neuropathology, Heidelberg, Germany.
• ³⁶ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard, MS #43, Los Angeles, CA, 90027, USA. ajudkins@chla.usc.edu.
• ³⁷ Department of Pathology, University of Michigan, Ann Arbor, MI, 48104, USA. svenneti@med.umich.edu.
• ³⁸ Pathology, University of Michigan Medical School, University of Michigan, 3520E MSRB 1, 1150 W. Medical Center Dr., Ann Arbor, MI, 41804, USA. svenneti@med.umich.edu.