Abstract
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
Keywords:
SARS-COV-2; epitopes; immunoinformatics; vaccine.
© 2020 Wiley Periodicals, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Betacoronavirus / genetics
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Betacoronavirus / immunology*
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Betacoronavirus / pathogenicity
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Binding Sites
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COVID-19
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COVID-19 Vaccines
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Computational Biology / methods
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Coronavirus Infections / immunology
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Coronavirus Infections / prevention & control*
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Coronavirus Infections / virology
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Epitopes / chemistry
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Epitopes / genetics
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Epitopes / immunology
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Epitopes, B-Lymphocyte / chemistry*
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Epitopes, B-Lymphocyte / genetics
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Epitopes, B-Lymphocyte / immunology
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Epitopes, T-Lymphocyte / chemistry*
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Epitopes, T-Lymphocyte / genetics
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Epitopes, T-Lymphocyte / immunology
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / genetics
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Histocompatibility Antigens Class I / immunology
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Histocompatibility Antigens Class II / chemistry
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Histocompatibility Antigens Class II / genetics
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Histocompatibility Antigens Class II / immunology
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Humans
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Middle East Respiratory Syndrome Coronavirus / genetics
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Middle East Respiratory Syndrome Coronavirus / immunology
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Middle East Respiratory Syndrome Coronavirus / pathogenicity
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Molecular Docking Simulation
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Pandemics / prevention & control*
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Pneumonia, Viral / immunology
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Pneumonia, Viral / prevention & control*
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Pneumonia, Viral / virology
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Protein Binding
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Protein Interaction Domains and Motifs
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Protein Structure, Tertiary
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SARS-CoV-2
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Severe acute respiratory syndrome-related coronavirus / genetics
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Severe acute respiratory syndrome-related coronavirus / immunology
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Severe acute respiratory syndrome-related coronavirus / pathogenicity
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Spike Glycoprotein, Coronavirus / chemistry*
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / immunology
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Toll-Like Receptor 5 / chemistry*
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Toll-Like Receptor 5 / genetics
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Toll-Like Receptor 5 / immunology
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Vaccines, Subunit
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Viral Vaccines / chemistry*
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Viral Vaccines / immunology
Substances
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COVID-19 Vaccines
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Epitopes
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Epitopes, B-Lymphocyte
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Epitopes, T-Lymphocyte
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Spike Glycoprotein, Coronavirus
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TLR5 protein, human
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Toll-Like Receptor 5
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Vaccines, Subunit
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Viral Vaccines
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spike protein, SARS-CoV-2