Abstract
A significant enhancement of interleukin-2 production was observed in phytohemagglutinin-stimulated peripheral lymphocytes from patients with progressive systemic sclerosis (PSS). Their Leu-3a:Leu-2a ratio was also significantly higher than normal. Moreover, Leu-3a+ cells freshly purified from PSS patients' blood produced much more interleukin-2 than did cells from normal subjects. These results suggest that T cell hyperactivity, especially among Leu-3a+ T cells, occurs in patients with PSS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antigens, Differentiation, T-Lymphocyte / analysis
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Antigens, Surface / analysis
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Female
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Flow Cytometry
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Humans
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Interleukin-2 / biosynthesis*
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Kinetics
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Leukocytes, Mononuclear / metabolism
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Leukocytes, Mononuclear / physiology
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Lymphocyte Activation
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Male
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Middle Aged
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Scleroderma, Systemic / metabolism*
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T-Lymphocytes / immunology
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T-Lymphocytes / physiology*
Substances
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Surface
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Interleukin-2