Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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B-Lymphocytes / pathology
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Cell Differentiation
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DNA, Recombinant
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Enhancer Elements, Genetic*
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Gene Expression Regulation
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Genes
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Genes, Regulator*
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Immunoglobulins / genetics*
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Lymphoma / genetics*
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Mice
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Oncogenes*
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Proto-Oncogene Proteins / genetics*
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Recombination, Genetic
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Transcription, Genetic
Substances
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DNA, Recombinant
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Immunoglobulins
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Proto-Oncogene Proteins