Abstract
Pathologists need to be more aware of the capacity of drugs, in particular non-steroidal anti-inflammatory agents, to produce a wide spectrum of lesions in the intestinal tract. Whilst the histological changes brought about by drugs are generally non-specific in character, certain features such as tissue eosinophilia, the presence of apoptotic bodies in the crypts of Leiberkhun or an increase in intra-epithelial lymphocytes in the colon should always raise the suspicion of drug effects.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Colitis / chemically induced
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Colitis / pathology
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Enteritis / chemically induced
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Enteritis / pathology
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Humans
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Intestinal Diseases / chemically induced*
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Intestinal Diseases / pathology
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / pathology*
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Intestinal Obstruction / chemically induced
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Intestinal Obstruction / pathology
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Intestine, Large / drug effects
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Intestine, Large / pathology*
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Intestine, Small / drug effects
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Intestine, Small / pathology*
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Ulcer / chemically induced
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Ulcer / pathology
Substances
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Anti-Inflammatory Agents, Non-Steroidal