Drug-related pathological lesions of the intestinal tract

Histopathology. 1994 Oct;25(4):303-8. doi: 10.1111/j.1365-2559.1994.tb01347.x.

Abstract

Pathologists need to be more aware of the capacity of drugs, in particular non-steroidal anti-inflammatory agents, to produce a wide spectrum of lesions in the intestinal tract. Whilst the histological changes brought about by drugs are generally non-specific in character, certain features such as tissue eosinophilia, the presence of apoptotic bodies in the crypts of Leiberkhun or an increase in intra-epithelial lymphocytes in the colon should always raise the suspicion of drug effects.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Colitis / chemically induced
  • Colitis / pathology
  • Enteritis / chemically induced
  • Enteritis / pathology
  • Humans
  • Intestinal Diseases / chemically induced*
  • Intestinal Diseases / pathology
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / pathology*
  • Intestinal Obstruction / chemically induced
  • Intestinal Obstruction / pathology
  • Intestine, Large / drug effects
  • Intestine, Large / pathology*
  • Intestine, Small / drug effects
  • Intestine, Small / pathology*
  • Ulcer / chemically induced
  • Ulcer / pathology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal