Abstract
The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Animals
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Cell Cycle / physiology*
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Cyclin-Dependent Kinase Inhibitor p16 / genetics
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Cyclin-Dependent Kinase Inhibitor p16 / physiology*
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Cyclin-Dependent Kinases / metabolism*
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Genes, p16
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Humans
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Mammals
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Models, Biological
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Neoplasms / genetics
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Neoplasms / pathology*
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Neoplasms / physiopathology*
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Proteins / genetics
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Retinoblastoma Protein / physiology
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Tumor Suppressor Protein p14ARF
Substances
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Cyclin-Dependent Kinase Inhibitor p16
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Proteins
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Retinoblastoma Protein
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Tumor Suppressor Protein p14ARF
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Cyclin-Dependent Kinases