There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Background A significant portion of cancers are accounted for by a heritable component,
which has increasingly been linked to mutations in specific genes. Clinical interventions …

The development of an oncogenic state is a complex process involving the accumulation of
multiple independent mutations that lead to deregulation of cell signalling pathways central …

Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers
susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The …

Previous studies have suggested that overexpression of HER-2/neu oncogene occurs in 15–
40% of breast cancers and that overexpression is associated with poor prognosis. In the …

Early detection remains the most promising approach to improve long-term survival of
patients with ovarian cancer. In a five-center case-control study, serum proteomic …

Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether
this risk extends to all invasive histological subtypes or borderline tumours is not clear. We …

Endometrial carcinomas represent the most common gynecological cancer in the United
States, yet the molecular genetic events that underlie the development of these tumors …

We examined p53 expression in 107 epithelial ovarian cancers with immunohistochemical
techniques using monoclonal antibody PAb1801. High level expression of nuclear p53 …