A 25-year computerised survey of deaths in the United Kingdom among diabetic patients of
19 years of age and under was performed. Suitable pancreatic material was available in 119 …

Tumour budding reflects a detachment of tumour cells at the invasive front of carcinomas
and is presumed to be an early step in the metastatic process. Tumour budding has received …

The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because
of the limited availability of appropriate samples, but we now report a detailed study charting …

IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1
(Th1) responses. We detected IL-18 mRNA and protein within rheumatoid arthritis (RA) …

INTRODUCTION: Components of the systemic inflammatory response, combined to form
inflammation-based prognostic scores (modified Glasgow Prognostic Score (mGPS) …

Type 1 diabetes is a chronic autoimmune disease characterised by the selective destruction
of pancreatic beta (β) cells. The understanding of the aetiology of this disease has increased …

Of 37 pancreases removed at necropsy from patients with type 1 diabetes 34 had residual β
cells. In 33 of the 34 the β cells were positive for immunoreactive α-interferon, and this …

Aims/hypothesis Evidence that the beta cells of human patients with type 1 diabetes can be
infected with enterovirus is accumulating, but it remains unclear whether such infections …

Methods: Patients (n= 21 669) who had an incidental blood sample taken between 2000
and 2006 for C-reactive protein, albumin and calcium (and liver function tests where …

In patients with multiple endocrine neoplasia type 1 (MEN-1), gastrinomas are common and
thought to occur predominantly in the pancreas. We describe eight patients with MEN-1 and …