Background Blood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB)
response are lacking. We hypothesized that changes in systemic cytokine levels with the …

Objectives In this study, we evaluated the impact of clinical sample handling and processing
on IL-6, IL-10, IFNγ, and IL-2 measurements in plasma. Design and methods We collected …

Therapeutic approaches for clear cell renal cell carcinoma (ccRCC) remain limited;
however, chimeric antigen receptor (CAR) T-cell therapies may offer novel treatment …

Objectives To evaluate peripheral blood (PB) for minimal residual disease (MRD)
assessment in adults with acute lymphoblastic leukaemia (ALL). Methods We analysed 76 …

TPS4165 Background: Fibroblast growth factor receptor 2b (FGFR2b) is overexpressed in
approximately 30% of non-human epidermal growth factor receptor 2 (non-HER2) positive …

Talimogene laherparepvec (T‐VEC) is approved for the treatment of unresectable
melanoma in the USA, Europe, and Australia. This phase I, multicenter, open‐label, dose de …

Context.—As laboratories increasingly turn from single-analyte testing in hematologic
malignancies to next-generation sequencing–based panel testing, there is a corresponding …

Single-molecule array (Simoa) technology enables ultrasensitive protein detection that is
suited to the development of peripheral blood-based assays for assessing immuno …

Context.—With the increasing integration of molecular alterations into the evaluation of
hematologic malignancies (HM), somatic mutation profiling by next-generation sequencing …

Objectives To develop a curriculum for a commercial reference laboratory clinical pathology
training elective. Methods A 4-day elective at Quest Diagnostics was developed. The …