[HTML][HTML] Structured evaluation of rodent behavioral tests used in drug discovery research

A Hånell, N Marklund - Frontiers in behavioral neuroscience, 2014 - frontiersin.org
A large variety of rodent behavioral tests are currently being used to evaluate traits such as
sensory-motor function, social interactions, anxiety-like and depressive-like behavior …

Neutralization of interleukin‐1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

F Clausen, A Hånell, M Björk, L Hillered… - European Journal of …, 2009 - Wiley Online Library
Abstract Interleukin‐1β (IL‐1β) may play a central role in the inflammatory response
following traumatic brain injury (TBI). We subjected 91 mice to controlled cortical impact …

Neutralization of interleukin‐1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

F Clausen, A Hånell, C Israelsson… - European Journal of …, 2011 - Wiley Online Library
Increasing evidence suggests that interleukin‐1β (IL‐1β) is a key mediator of the
inflammatory response following traumatic brain injury (TBI). Recently, we showed that …

Mild traumatic brain injury in the mouse induces axotomy primarily within the axon initial segment

JE Greer, A Hånell, MJ McGinn, JT Povlishock - Acta neuropathologica, 2013 - Springer
Traumatic axonal injury (TAI) is a consistent component of traumatic brain injury (TBI), and is
associated with much of its morbidity. Increasingly, it has also been recognized as a major …

Autoregulatory management in traumatic brain injury: the role of absolute pressure reactivity index values and optimal cerebral perfusion pressure curve shape

T Svedung Wettervik, A Hånell, T Howells… - Journal of …, 2023 - liebertpub.com
The aim of this study was to investigate if the absolute pressure reactivity index (PRx) value
influenced the association between cerebral perfusion pressure (CPP) and outcome and if …

[HTML][HTML] Thiopental and decompressive craniectomy as last-tier ICP-treatments in aneurysmal subarachnoid hemorrhage: is functional recovery within reach?

S Björk, A Hånell, E Ronne-Engström, A Stenwall… - Neurosurgical …, 2023 - Springer
The study aimed to investigate the indication and functional outcome after barbiturates and
decompressive craniectomy (DC) as last-tier treatments for elevated intracranial pressure …

Traumatic brain injury-induced axonal phenotypes react differently to treatment

A Hånell, JE Greer, MJ McGinn, JT Povlishock - Acta neuropathologica, 2015 - Springer
Injured axons with distinct morphologies have been found following mild traumatic brain
injury (mTBI), although it is currently unclear whether they reflect varied responses to the …

ICP, CPP, and PRx in traumatic brain injury and aneurysmal subarachnoid hemorrhage: association of insult intensity and duration with clinical outcome

TS Wettervik, A Hånell, T Howells, ER Engström… - Journal of …, 2022 - thejns.org
OBJECTIVE The primary aim of this study was to determine the combined effect of insult
intensity and duration of intracranial pressure (ICP), cerebral perfusion pressure (CPP), and …

Monitoring of β-amyloid dynamics after human traumatic brain injury

N Marklund, N Farrokhnia, A Hånell… - Journal of …, 2014 - liebertpub.com
Epidemiological evidence links severe or repeated traumatic brain injury (TBI) to the
development of Alzheimer's disease (AD). Accumulation of amyloid precursor protein (APP) …

Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats

K Magnusson, A Hånell, I Bazov, F Clausen, Q Zhou… - Neuroscience …, 2009 - Elsevier
The misuse of anabolic androgenic steroids has in several reports been associated with
effects resulting in altered behavior. This study used the Morris water maze task to …