According to the present view, metastasis marks the end in a sequence of genomic changes
underlying the progression of an epithelial cell to a lethal cancer. Here, we aimed to find out …

Introduction Lymphocyte infiltration (LI) is often seen in breast cancer but its importance
remains controversial. A positive correlation of human epidermal growth factor receptor 2 …

Introduction Current prognostic gene expression profiles for breast cancer mainly reflect
proliferation status and are most useful in ER-positive cancers. Triple negative breast …

Background Current prognostic gene signatures for breast cancer mainly reflect proliferation
status and have limited value in triple-negative (TNBC) cancers. The identification of …

We previously used DNA array analyses in the molecular profiling of breast cancers. By
cluster analysis of 55 patients, we identified a subpopulation of breast cancers—designated …

The retinoblastoma protein (pRB), p16, and cyclin D1 are major components of the RB
pathway, which controls the G1 checkpoint of the cell cycle. Proper regulation of this …

For many tumuors, pathological subclasses exist which have to be further defined by genetic
markers to improve therapy and follow‐up strategies. In this study, cDNA array analyses of …

Purpose: A common characteristic of mammary carcinomas is an inverse relationship
between the estrogen receptor (ER) status and the proliferative activity of the tumor. Yet, a …

Pooling of microarray datasets seems to be a reasonable approach to increase sample size
when a heterogeneous disease like breast cancer is concerned. Different methods for the …

BACKGROUND: Molecular markers displaying bimodal expression distribution can reveal
distinct disease subsets and may serve as prognostic or predictive markers or represent …