Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

Parent-of-origin effects were first recorded> 3000 years ago by mule breeders in Asia Minor.
There are now several different types of evidence suggesting the presence of a large …

The identification of genes predisposing to familial cancer is an essential step towards
understanding the molecular events underlying tumorigenesis and is critical for the clinical …

GENOMIC imprinting has been implicated in the onset of several embryonal tumours but the
mechanism is not well understood1–3. Maternal chromosome 11p15 loss of heterozygosity4 …

To extend earlier observations of germline E‐cadherin mutations in kindreds with an
inherited susceptibility to diffuse gastric cancer, we searched for germline E‐cadherin …

Abstract Background The National Wilms Tumor Study (NWTS) constitutes a unique
resource for study of clinical, pathologic, and epidemiologic features of Wilms tumor (WT) …

Wilms' tumour probably arises from embryonal kidney cells and occurs in both hereditary
and sporadic forms1. Knudson and Strong have suggested that both forms of the disease …

Purpose: This study aimed to develop gene classifiers to predict colorectal cancer
recurrence. We investigated whether gene classifiers derived from two tumor series using …

The initial development of diffuse gastric cancer (DGC) is poorly understood. The study of E-
cadherin (CDH1) germ line mutation carriers predisposed to DGC provides a rare …

The insulin-like growth factors, IGF1 and IGF2, play a fundamental role in human fetal
growth. Of the growth disorders that involve excessive growth, many could be attributable to …