The use of immunohistochemistry (IHC) in clinical cohorts is of paramount importance in
determining the utility of a biomarker in clinical practice. A major bottleneck in translating a …

A hypothesis is discussed that the adaptive immune system of vertebrates evolved in the
gastrointestinal regions of primitive jawed fish (placoderms) due to increased localized …

The clinical significance of the tumor‐immune interaction in breast cancer is now
established, and tumor‐infiltrating lymphocytes (TILs) have emerged as predictive and …

Modern histologic imaging platforms coupled with machine learning methods have provided
new opportunities to map the spatial distribution of immune cells in the tumor …

While immune checkpoint–based immunotherapy (ICI) shows promising clinical results in
patients with cancer, only a subset of patients responds favorably. Response to ICI is …

Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several
cancer indications. Bvz response heterogeneity has been well documented, with only 10 …

Clinical workflows in oncology depend on predictive and prognostic biomarkers. However,
the growing number of complex biomarkers contributes to costly and delayed decision …

Despite the introduction of novel targeted therapies, chemotherapy still remains the primary
treatment for metastatic melanoma in poorly funded healthcare environments or in case of …

Simple Summary This research investigates the disease relevance and therapeutic potential
of cysteinyl leukotriene receptors in uveal melanoma (UM), a rare eye cancer that often …

Breast cancer is the most common disease among women, with over 2.1 million new
diagnoses each year worldwide. About 30% of patients initially presenting with early stage …