User profiles for "author:Ayse Ayhan"

Ayse Ayhan

Professor of Pathology
Verified email at hacettepe.edu.tr
Cited by 8746

[HTML][HTML] High grade serous ovarian carcinomas originate in the fallopian tube

SI Labidi-Galy, E Papp, D Hallberg, N Niknafs… - Nature …, 2017 - nature.com
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer
and has a poor outcome. It has been proposed that fallopian tube cancers may be …

Pathology and pathogenesis of adenomyosis

MF Antero, A Ayhan, J Segars… - Seminars in reproductive …, 2020 - thieme-connect.com
Adenomyosis represents a unique pathophysiological condition in which normal-appearing
endometrial mucosa resides within myometrium and is thus protected from menstrual …

[HTML][HTML] Cancer-associated mutations in endometriosis without cancer

MS Anglesio, N Papadopoulos, A Ayhan… - … England Journal of …, 2017 - Mass Medical Soc
Background Endometriosis, defined as the presence of ectopic endometrial stroma and
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic …

Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma

KT Kuo, TL Mao, S Jones, E Veras, A Ayhan… - The American journal of …, 2009 - Elsevier
Ovarian clear cell carcinoma (CCC) is one of the most malignant types of ovarian
carcinomas, particularly at advanced stages. Unlike the more common type of ovarian …

The inflammatory cytokine tumor necrosis factor-α generates an autocrine tumor-promoting network in epithelial ovarian cancer cells

H Kulbe, R Thompson, JL Wilson, S Robinson… - Cancer research, 2007 - AACR
Constitutive expression of the inflammatory cytokine tumor necrosis factor-α (TNF-α) is
characteristic of malignant ovarian surface epithelium. We investigated the hypothesis that …

Mature cystic teratomas of the ovary: case series from one institution over 34 years

A Ayhan, O Bukulmez, C Genc, BS Karamursel… - European Journal of …, 2000 - Elsevier
Objective: To evaluate bilaterality, complications and malignant changes of mature cystic
teratomas of the ovary. Study design: Retrospective study of 501 patients operated at …

Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma

A Ayhan, TL Mao, T Seckin, CH Wu, B Guan… - International Journal of …, 2012 - ijgc.bmj.com
Objectives ARID1A is a recently identified tumor suppressor participating in chromatin
remodeling. Somatic inactivating mutations of ARID1A and loss of its expression occur …

Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 …

E Veras, TL Mao, A Ayhan, S Ueda, H Lai… - The American journal …, 2009 - journals.lww.com
Ovarian clear cell carcinomas (CCC) typically present as large adnexal, stage I tumors and
are generally considered highly malignant. They are frequently associated with …

[PDF][PDF] Inhibition of spleen tyrosine kinase potentiates paclitaxel-induced cytotoxicity in ovarian cancer cells by stabilizing microtubules

Y Yu, S Gaillard, JM Phillip, TC Huang, SM Pinto… - Cancer cell, 2015 - cell.com
Resistance to chemotherapy represents a major obstacle for long-term remission, and
effective strategies to overcome drug resistance would have significant clinical impact. We …

Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas

W Yasui, A Ayhan, Y Kitadai… - … journal of cancer, 1993 - Wiley Online Library
We examined the expression of p34cdc2 and its kinase activity in human gastric and colonic
carcinoma cell lines and carcinoma tissues and studied its relation with a tumor‐suppressor …