TCRαβ+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder

…, A Izarra, S Fonseca, C Bueno, B Justiça… - The American journal of …, 2003 - Elsevier
Large granular lymphocyte (LGL) leukemia is a well-recognized disease of mature T-CD8+
or less frequently natural killer cells; in contrast, monoclonal expansions of CD4+ T-LGL …

Immunophenotypic analysis of the TCR-Vβ repertoire in 98 persistent expansions of CD3+/TCR-αβ+ large granular lymphocytes: utility in assessing clonality and …

…, ML Queirós, A Balanzategui, B Justiça… - The American journal of …, 2001 - Elsevier
At present, a major challenge in the initial diagnosis of leukemia of large granular
lymphocytes (LGLs) is to establish the clonal nature of the expanded population. In the …

Immunophenotypic aberrations, DNA content, and cell cycle analysis of plasma cells in patients with myeloma and monoclonal gammopathies

…, P Ribeiro, L Xavier, H Vieira, P Pinto, B Justiça - Blood Cells, Molecules …, 2000 - Elsevier
We describe the immunophenotypic and gross DNA defects in 55 patients with myeloma
and 50 patients with monoclonal gammopathy and review the literature on this subject …

Relative impact of HLA phenotype and CD4–CD8 ratios on the clinical expression of hemochromatosis

…, J Fraga, G Macedo, BM Silva, H Alves, B Justiça… - Hepatology, 1997 - journals.lww.com
Hemochromatosis is a hereditary iron–overload disease linked to HLA. The clinical
expression of hemochromatosis is influenced by sex and age. However, other factors must …

Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56−/+ dim chronic natural killer cell large granular lymphocytosis

…, L Pinho, M Gonzalez, J San Miguel, B Justiça… - The American journal of …, 2004 - Elsevier
Indolent natural killer (NK) cell lymphoproliferative disorders include a heterogeneous group
of patients in whom persistent expansions of mature, typically CD56+, NK cells in the …

Immunophenotypic characterization of normal blood CD56+ lo versus CD56+ hi NK-cell subsets and its impact on the understanding of their tissue distribution and …

…, ML Queirós, M Leite, AH Santos, B Justiça… - Blood Cells, Molecules …, 2001 - Elsevier
In the present study we have compared the immunophenotypic characteristics of the CD56+
lo and CD56+ hi NK-cell subsets in a group of normal healthy adults. Our results show that …

Haemochromatosis as a window into the study of the immunological system: A novel correlation between CD8+ lymphocytes and iron overload

…, C Gonçalves, C Vicente, B Justiça… - European journal of …, 1994 - Wiley Online Library
In the present study we report a serial investigation of the numbers of the peripheral blood
cells—erythrocytes, polymorphonuclear neutrophils, total lymphocytes, T‐lymphocyte …

Immunophenotype and TCR-Vβ repertoire of peripheral blood T-cells in acute infectious mononucleosis

…, JMN Soares, J úlia Almeida, A Orfao, B Justiça - Blood Cells, Molecules …, 2003 - Elsevier
Although a number of studies on the phenotypic changes that occur after T-cell activation
have already been published, the specific immunophenotypic features of T-lymphocytes and …

Major histocompatibility complex class I associations in iron overload: evidence for a new link between the HFE H63D mutation, HLA-A29, and non-classical forms of …

…, P Rodrigues, JM Cabeda, C Portal, A Ruivo, B Justiça… - Immunogenetics, 1998 - Springer
The present study is an analysis of the frequencies of HFE mutations in patients with
different forms of iron overload compared with the frequencies found in healthy subjects from …

The “ex vivo” patterns of CD2/CD7, CD57/CD11c, CD38/CD11b, CD45RA/CD45RO, and CD11a/HLA-DR expression identify acute/early and chronic/late NK-cell …

…, M dos Anjos Teixeira, ML Queirós, B Justiça… - Blood Cells, Molecules …, 2002 - Elsevier
To define a dynamic sequence of phenotypic changes related to early and late phases of NK-
cell activation, we have analyzed by four-color flow cytometry the immunophenotype of …