[HTML][HTML] Challenges and controversies in resectable non-small cell lung cancer: a clinician's perspective

I Houda, C Dickhoff, CA Uyl-de Groot… - The Lancet Regional …, 2024 - thelancet.com
The treatment landscape of resectable early-stage non-small cell lung cancer (NSCLC) is
transforming due to the approval of novel adjuvant and neoadjuvant systemic treatments …

[HTML][HTML] New systemic treatment paradigms in resectable non-small cell lung cancer and variations in patient access across Europe

I Houda, C Dickhoff, CA Uyl-de Groot… - The Lancet Regional …, 2024 - thelancet.com
The treatment landscape of resectable early-stage non-small cell lung cancer (NSCLC) is
set to change significantly due to encouraging results from randomized trials evaluating …

Delayed microvascular shear adaptation in pulmonary arterial hypertension. Role of platelet endothelial cell adhesion molecule-1 cleavage

R Szulcek, CM Happe, N Rol, RD Fontijn… - American journal of …, 2016 - atsjournals.org
Rationale: Altered pulmonary hemodynamics and fluid flow–induced high shear stress
(HSS) are characteristic hallmarks in the pathogenesis of pulmonary arterial hypertension …

Salvage surgery for recurrent or persistent tumour after radical (chemo) radiotherapy for locally advanced non-small cell lung cancer: a systematic review

C Dickhoff, RHJ Otten, MW Heymans… - … advances in medical …, 2018 - journals.sagepub.com
Background: Once recurrent or persistent locoregional tumour after radical
chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is identified, few curative …

Epigenetic modification of the von Willebrand factor promoter drives platelet aggregation on the pulmonary endothelium in chronic thromboembolic pulmonary …

XD Manz, R Szulcek, X Pan, P Symersky… - American journal of …, 2022 - atsjournals.org
Rationale: von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While
chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased …

Endobronchial treatment for bronchial carcinoid: patient selection and predictors of outcome

EMBP Reuling, C Dickhoff, PW Plaisier, VMH Coupé… - Respiration, 2018 - karger.com
Background: Traditionally, surgical resection is the preferred treatment for typical carcinoids
and atypical carcinoids located in the lungs. Recently however, several studies have shown …

Persistent postthyroidectomy hypoparathyroidism in the Netherlands

I Lončar, ME Noltes, C Dickhoff… - … –Head & Neck …, 2021 - jamanetwork.com
Importance Hypoparathyroidism is one of the most common complications after total or
completion thyroidectomy. The reported incidence rate of hypoparathyroidism in the …

[HTML][HTML] Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

R Szulcek, G Sanchez-Duffhues, N Rol, X Pan… - Angiogenesis, 2020 - Springer
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP)
signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype …

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

N Rol, MA de Raaf, XQ Sun, VP Kuiper… - Cardiovascular …, 2019 - academic.oup.com
Aims Pulmonary arterial hypertension (PAH) is associated with increased levels of
circulating growth factors and corresponding receptors such as platelet derived growth …

[HTML][HTML] Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0–1 non-small cell lung …

C Dickhoff, S Senan, FL Schneiders, J Veltman… - BMC cancer, 2020 - Springer
Background The likelihood of a tumor recurrence in patients with T3-4N0–1 non-small cell
lung cancer following multimodality treatment remains substantial, mainly due distant …