[HTML][HTML] United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

HA Oketch-Rabah, AL Roe, CV Rider, HL Bonkovsky… - Toxicology reports, 2020 - Elsevier
As part of the United States Pharmacopeia's ongoing review of dietary supplement safety
data, a new comprehensive systematic review on green tea extracts (GTE) has been …

Treating chronic hepatitis delta: the need for surrogate markers of treatment efficacy

C Yurdaydin, Z Abbas, M Buti, M Cornberg… - Journal of …, 2019 - Elsevier
Chronic hepatitis delta represents the most severe form of chronic viral hepatitis. The current
treatment of hepatitis delta virus (HDV) infection consists of the use of interferons and is …

Pathogenesis of and new therapies for hepatitis D

C Koh, T Heller, JS Glenn - Gastroenterology, 2019 - Elsevier
Hepatitis delta virus (HDV) infection of humans was first reported in 1977, and now it is now
estimated that 15–20 million people are infected worldwide. Infection with HDV can be an …

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

HS Kuehn, W Ouyang, B Lo, EK Deenick, JE Niemela… - Science, 2014 - science.org
Cytotoxic T lymphocyte antigen–4 (CTLA-4) is an inhibitory receptor found on immune cells.
The consequences of mutations in CTLA4 in humans are unknown. We identified germline …

[PDF][PDF] The association of genetic variability in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver …

Y Rotman, C Koh, JM Zmuda, DE Kleiner… - …, 2010 - Wiley Online Library
Genome‐wide association studies identified single‐nucleotide polymorphisms (SNPs) that
are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting …

An experimental investigation of concentrated suspension flows in a rectangular channel

CJ Koh, P Hookham, LG Leal - Journal of Fluid Mechanics, 1994 - cambridge.org
An experimental adaptation of the well-known laser-Doppler anemometry technique is
developed for measuring the velocity and concentration profiles in concentrated suspension …

Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection

NG Sandler, C Koh, A Roque, JL Eccleston, RB Siegel… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Chronic infection with hepatitis B or C virus (HBV or HCV) is a
leading cause of cirrhosis by unknown mechanisms of pathogenesis. Translocation of gut …

Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa–dependent manner

G Ahlenstiel, RH Titerence, C Koh, B Edlich, JJ Feld… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infection display great
variability in disease activity and progression. Although virus-specific adaptive immune …

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

C Koh, L Canini, H Dahari, X Zhao… - The Lancet Infectious …, 2015 - thelancet.com
Background Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory.
Prenylation is essential for HDV and inhibition abrogates HDV production in experimental …

[PDF][PDF] Point mutations in exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant

J Li, SL Woods, S Healey, J Beesley, X Chen… - The American Journal of …, 2016 - cell.com
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal-
dominant cancer-predisposition syndrome with a significant risk of gastric, but not colorectal …