User profiles for "author:D C Gaze"

David C Gaze

Senior Lecturer in Chemical Pathology
Verified email at westminster.ac.uk
Cited by 12817

In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated …

KU Schallreuter, J Moore, JM Wood… - Journal of Investigative …, 1999 - Elsevier
To date there is compelling in vitro and in vivo evidence for epidermal H 2 O 2 accumulation
in vitiligo. This paper reviews the literature and presents new data on oxidative stress in the …

Cardiac troponins: from myocardial infarction to chronic disease

KC Park, DC Gaze, PO Collinson… - Cardiovascular …, 2017 - academic.oup.com
Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our
understanding of cardiac contraction. Although troponins are expressed in both skeletal and …

Measurement of cardiac troponins

PO Collinson, FG Boa, DC Gaze - Annals of clinical …, 2001 - journals.sagepub.com
The cardiac troponins form part of the regulatory mechanism for muscle contraction. Specific
cardiac isoforms of cardiac troponin T and cardiac troponin I exist and commercially …

Role of “Ischemia modified albumin”, a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes

MK Sinha, D Roy, DC Gaze, PO Collinson, JC Kaski - Heart, 2004 - heart.bmj.com
Background: Diagnosis of cardiac ischaemia in patients attending emergency departments
(ED) with symptoms of acute coronary syndromes is often difficult. Cardiac troponin (cTn) is …

Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention

MK Sinha, DC Gaze, JR Tippins, PO Collinson… - Circulation, 2003 - Am Heart Assoc
Background—Ischemia modified albumin (IMA; Ischemia Technologies, Inc) blood levels
rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is …

Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin

D Roy, J Quiles, DC Gaze, P Collinson, JC Kaski… - Heart, 2006 - heart.bmj.com
MATERIALS AND METHODS All reagents were obtained from Sigma-Aldrich (Poole, Dorset,
UK) and normal human serum from the North London Transfusion Service (London, UK) …

[HTML][HTML] Exercise-induced cardiac troponin T release: a meta-analysis

R Shave, K George, G Atkinson… - … & Science in …, 2007 - westminsterresearch.westminster.ac …
PURPOSE: Cardiac troponin T (cTnT) is a highly specific marker of myocardial damage and
used clinically in the diagnosis of acute myocardial infarction (AMI). Release of cTnT has …

Mitral peak Doppler E-wave to peak mitral annulus velocity ratio is an accurate estimate of left ventricular filling pressure and predicts mortality in end-stage renal …

R Sharma, D Pellerin, DC Gaze, RL Mehta… - Journal of the American …, 2006 - Elsevier
OBJECTIVE: The study aimed to assess whether the mitral peak Doppler E-wave to peak
mitral annulus velocity ratio (E/Ea) estimates left ventricular (LV) filling pressure (LVFP) and …

Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia

DC Gaze - Drug metabolism and pharmacokinetics, 2009 - Elsevier
The diagnosis of cardiac ischemia remains a challenge in contemporary emergency
medicine. A blood-borne biomarker is an attractive alternative to cardiac imaging or stress …

Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care

P Hildebrandt, PO Collinson, RN Doughty… - European heart …, 2010 - academic.oup.com
Aims The study evaluated the use of age-related decision limits for N-terminal pro-B-type
natriuretic peptide (NT-proBNP), for ruling out suspected systolic dysfunction in symptomatic …