Inhibition of natural killer cell activation signals by killer cell immunoglobulin‐like receptors (CD158)

EO Long, DF Barber, DN Burshtyn… - Immunological …, 2001 - Wiley Online Library
The killer cell immunoglobulin‐like receptor (KIR) family includes receptors that bind to HLA
class I molecules on target cells and inhibit natural killer (NK)‐cell cytotoxicity, and receptors …

[HTML][HTML] The use of iron oxide nanoparticles to reprogram macrophage responses and the immunological tumor microenvironment

V Mulens-Arias, JM Rojas, DF Barber - Frontiers in immunology, 2021 - frontiersin.org
The synthesis and functionalization of iron oxide nanoparticles (IONPs) is versatile, which
has enhanced the interest in studying them as theranostic agents over recent years. As …

[HTML][HTML] Understanding MNPs behaviour in response to AMF in biological milieus and the effects at the cellular level: Implications for a rational design that drives …

D Egea-Benavente, JG Ovejero, MP Morales… - Cancers, 2021 - mdpi.com
Simple Summary Magnetic hyperthermia therapy is an alternative treatment for cancer that
complements traditional therapies and that has shown great promise in recent years. In this …

Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells

YT Bryceson, ME March, DF Barber… - The Journal of …, 2005 - rupress.org
The relative contribution to cytotoxicity of each of the multiple NK cell activation receptors
has been difficult to assess. Using Drosophila insect cells, which express ligands of human …

PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

DF Barber, A Bartolomé, C Hernandez, JM Flores… - Nature medicine, 2005 - nature.com
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by
deregulation of T cell–mediated B-cell activation, which results in glomerulonephritis and …

LFA-1 contributes an early signal for NK cell cytotoxicity

DF Barber, M Faure, EO Long - The Journal of Immunology, 2004 - journals.aai.org
Cytotoxicity of human NK cells is activated by receptors that bind ligands on target cells, but
the relative contribution of the many different activating and inhibitory NK cell receptors is …

[PDF][PDF] NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

RE Voll, E Jimi, RJ Phillips, DF Barber, M Rincon… - Immunity, 2000 - cell.com
Activation of the transcription factor NF-κB and pre-T cell receptor (pre-TCR) expression is
tightly correlated during thymocyte development. Inhibition of NF-κB in isolated thymocytes …

Dimercaptosuccinic acid-coated magnetite nanoparticles for magnetically guided in vivo delivery of interferon gamma for cancer immunotherapy

R Mejías, S Pérez-Yagüe, L Gutiérrez, LI Cabrera… - Biomaterials, 2011 - Elsevier
As radio-and chemotherapy-based cancer treatments affect both tumors and healthy tissue,
cancer immunotherapy attempts to specifically enhance the natural immune response to …

Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis

C Gómez-Moutón, RA Lacalle, E Mira… - The Journal of cell …, 2004 - rupress.org
Spatially restricted activation of signaling molecules governs critical aspects of cell
migration; the mechanism by which this is achieved nonetheless remains unknown. Using …

p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

A Risco, C del Fresno, A Mambol… - Proceedings of the …, 2012 - National Acad Sciences
On the basis mainly of pharmacological experiments, the p38α MAP kinase isoform has
been established as an important regulator of immune and inflammatory responses …